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NR1I2 / PXR
nuclear receptor subfamily 1, group I, member 2
Pregnane X receptor (PXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to mediate the effects of steroid hormones, including progesterone, glucocorticoid, and pregnenolone, and effects of xenobiotics, through the cytochrome P-450 3A gene family (CYP3A). PXR protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. PXR also has been suggested to regulate drug efflux by activating expression of the MDR1 gene, control the biosynthesis and metabolism of bile acids, and influence the protection of the feto-maternal system from the toxic effects of endogenous steroids and foreign substrates. PXR binds as a heterodimer (with RXR) to the CYP3A promoter region. At least six protein isoforms, produced by alternative splicing, have been reported.
| Gene Name: | nuclear receptor subfamily 1, group I, member 2 |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | NR1I2, BXR, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, PARq, PRR, PXR, Pregnane X receptor, ONR1, SAR, SXR |
| Target Sequences: | NM_003889 NP_003880.3 O75469 |
Publications (5)
1
Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Chen Y, Tang Y, Wang MT, Zeng S, Nie D. Cancer research. 2007 67:10361-7.
[PubMed:17974979]
2
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Molecular endocrinology (Baltimore, Md.). 2008 22:838-57.
[PubMed:18096694]
3
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Gupta D, Venkatesh M, Wang H, Kim S, Sinz M, Goldberg GL, Whitney K, Longley C, Mani S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 14:5332-40.
[PubMed:18765524]
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(55)
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(55)
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NR1I2 / PXR
(55)
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(39)
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(12)
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(6)
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(3)
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(7)
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(53)
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(3)
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(12)
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(52)
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(27)
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(1)
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(1)
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(2)
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(53)
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(8)
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(3)
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(21)
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(8)
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(8)
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(4)
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(4)
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(1)
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(1)
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(1)
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(1)
Publications
No
(55)
NR1I2 / PXR Goat anti-Human Polyclonal (aa406-420) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
NR1I2 / PXR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100 µg/$331
NR1I2 / PXR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
NR1I2 / PXR Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$442
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa100-127) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa108-157) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa108-157) (HRP) Antibody
Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa108-157) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa108-157) (FITC) Antibody
Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR1I2 / PXR Rabbit anti-Mouse Polyclonal (aa205-390) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
NR1I2 / PXR Rabbit anti-Mouse Polyclonal (aa205-390) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
NR1I2 / PXR Rabbit anti-Mouse Polyclonal (aa205-390) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
NR1I2 / PXR Mouse anti-Human Monoclonal (6H11D8) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
NR1I2 / PXR Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
NR1I2 / PXR Rabbit anti-Rat Polyclonal (aa246-431) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
NR1I2 / PXR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NR1I2 / PXR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa175-434) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
NR1I2 / PXR Mouse anti-Human Monoclonal (1D12G1) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
NR1I2 / PXR Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR1I2 / PXR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NR1I2 / PXR Rabbit anti-Human Polyclonal (60-140 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa100-127) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
NR1I2 / PXR Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
NR1I2 / PXR Rabbit anti-Human Polyclonal (aa91-140) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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