NOTCH2

notch 2

NOTCH2 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

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Proteins (4)

Type

Recombinant (4)

Target

NOTCH2 (4)

Publications

No (4)

Tag

6His, C-terminus (1)

GST, N-terminus (1)

His, N-Terminal (1)

Human IgG1 Fc (1)

Species

Human (3)

Mouse (1)

Source

CHO Cells (1)

E. coli (1)

Human (1)

Wheat Germ Extract (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human NOTCH2 Protein (Recombinant His, N-Terminal) (aa2251-2466) - LS-G16106

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human NOTCH2 Protein (Recombinant GST, N-terminus) (aa27-136) - LS-G59429

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NOTCH2 Protein (Recombinant 6His, C-terminus) - LS-G146163

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

54.9 kDa

Price:

10 µg/$308; 50 µg/$502

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Mouse NOTCH2 Protein (Recombinant Human IgG1 Fc) (aa26-494) - LS-G3940

Source:

CHO Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~87kDa (SDS-PAGE)

Price:

50 µg/$379

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