NOTCH2

notch 2

NOTCH2 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

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Products

Antibodies (58)

ELISA Kits (7)

Proteins (4)

Type

Custom (3)

Primary (58)

Recombinant (4)

Sandwich (4)

Target

NOTCH2 (69)

Reactivity

Human (52)

Mouse (29)

Rat (22)

Bat (5)

Bovine (5)

Chimpanzee (4)

Dog (6)

Gibbon (3)

Monkey (5)

Pig (4)

Rabbit (1)

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Application

IHC (19)

IHC-P (11)

WB (39)

Flo (6)

ELISA (18)

IF (2)

IP (4)

Peptide-ELISA (5)

Host

rabbit (47)

mouse (3)

goat (1)

hamster (6)

rat (1)

Product Group

IHCPlus (4)

PathPlus Neuro (1)

Isotype

IgG (28)

IgG,k (2)

IgG1,k (2)

IgG2a (1)

Clonality

monoclonal mc (9)

polyclonal pc (45)

recombinant monoclonal rmc (4)

Clone

12G37 (1)

8A1 (1)

B6 (2)

B9 (2)

HMN2-35 (1)

NOD-15 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

APC (1)

APC Conjugated (1)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (41)

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Epitope

aa2251-2466 (8)

Notch 2 (4)

aa2376-2425 (4)

N-Terminus (3)

Internal (2)

aa2421-2471 (2)

1650-1730 aa, Internal (1)

1660-1740 aa, Internal (1)

1690-1770 aa, Internal (1)

Cleaved Ala1734 (1)

Cleaved Asp1733 (1)

Cleaved-Ala1734 (1)

Cleaved-Asp1733 (1)

Cleaved-Val1697 (1)

aa1550-1600 (1)

aa1678-1727 (1)

aa1715-1764 (1)

aa2063-2413 (1)

aa2250-2300 (1)

aa2390-2415 (1)

aa2396-2409 (1)

aa2399-2412 (1)

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Publications

No (67)

Yes (2)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

6His, C-terminus (1)

GST, N-terminus (1)

His, N-Terminal (1)

Human IgG1 Fc (1)

Species

Human (3)

Mouse (1)

Source

CHO Cells (1)

E. coli (1)

Human (1)

Wheat Germ Extract (1)

Low Endotoxin Level

Low endotoxin level (2)

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IHC-plus™ NOTCH2 Antibody (N-Terminus) LS-B719

(5.0) Rating

(1) Publication(s)

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

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PathPlus™ NOTCH2 Antibody (aa2390-2415) LS-B399

Neuroscience

(5.0) Rating

(3) Publication(s)

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (aa2390-2415) Antibody

Reactivity:

Dog, Human, Chimpanzee

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

Select

NOTCH2 Antibody (clone NOD-15) LS-C191107

Antibody:

NOTCH2 Rabbit anti-Human Monoclonal (NOD-15) Antibody

Reactivity:

Rat, Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

20 µl/$480; 100 µl/$751

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NOTCH2 Antibody LS-C126054

Antibody:

NOTCH2 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$628

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NOTCH2 Antibody (Cleaved-Val1697) LS-C821729

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (Cleaved-Val1697) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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NOTCH2 Antibody (clone 8A1) LS-C73704

Antibody:

NOTCH2 Rabbit anti-Human Monoclonal (8A1) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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Human NOTCH2 Protein (Recombinant His, N-Terminal) (aa2251-2466) - LS-G16106

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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NOTCH2 Antibody (N-Terminus) LS-C744599

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

25 µl/$304

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NOTCH2 Antibody LS-C674120

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

NOTCH2 Antibody (Internal) LS-C352592

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

NOTCH2 Antibody (1690-1770 aa, Internal) LS-C380510

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (1690-1770 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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NOTCH2 Antibody (clone HMN2-35) LS-C188663

Antibody:

NOTCH2 Hamster anti-Mouse Monoclonal (HMN2-35) Antibody

Reactivity:

Mouse

Applications:

Flo

Format:

Unconjugated

Price:

0.1 mg/$395; 0.25 mg/$486

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NOTCH2 Antibody (clone 12G37) LS-C182623

Antibody:

NOTCH2 Hamster anti-Mouse Monoclonal (12G37) Antibody

Reactivity:

Mouse, Rat

Applications:

Flo

Format:

Unconjugated

Price:

100 µg/$572; 250 µg/$771

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NOTCH2 Antibody (aa2376-2425) LS-C109704

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (aa2376-2425) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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NOTCH2 Antibody (Cleaved Asp1733) LS-C801402

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (Cleaved Asp1733) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NOTCH2 Antibody (aa2396-2409) LS-C9341

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (aa2396-2409) Antibody

Reactivity:

Dog, Bovine, Bat, Human, Monkey

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$634

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Human NOTCH2 (Sandwich ELISA) ELISA Kit - LS-F12174

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human NOTCH2 (Sandwich ELISA) ELISA Kit - LS-F9191

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$792

Select

IHC-plus™ NOTCH2 Antibody LS-A12862

Fast Shipping

(4.0) Rating

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ NOTCH2 Antibody LS-A12890

Fast Shipping

(4.0) Rating

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

NOTCH2 Antibody (aa2421-2471) LS-C288845

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (aa2421-2471) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

NOTCH2 Antibody (aa2250-2300) LS-C288847

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (aa2250-2300) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

IHC-plus™ NOTCH2 Antibody LS-A12878

Fast Shipping

(4.0) Rating

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

NOTCH2 Antibody (N-Terminus) LS-C124296

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$780

Select

NOTCH2 Antibody (1660-1740 aa, Internal) LS-C380511

Antibody:

NOTCH2 Rabbit anti-Human Polyclonal (1660-1740 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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