NOG / Noggin

noggin

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

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Products

Proteins (31)

Type

Native (1)

Over-Expression Lysate (2)

Recombinant (28)

Target

NOG / Noggin (31)

Format

Animal-free (1)

Publications

No (31)

Tag

6His, C-terminus (1)

6His, N-terminus (1)

Fc (1)

Fc, C-terminus (1)

GST (1)

His (5)

His,C-terminus (2)

His-GST (1)

His-GST, N-terminus (2)

His-MBP (1)

His-MBP, N-terminus (1)

Myc-DDK (Flag) (2)

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Species

Chicken (1)

Dog (1)

Human (15)

Mouse (8)

Pig (1)

Rat (4)

Source

293T Cells (1)

CHO Cells (3)

E. coli (16)

HEK 293 Cells (4)

Human Cells (1)

Mammalian Cells (4)

Rat (1)

Wheat Germ Extract (1)

Purification

Purified (10)

Low Endotoxin Level

Low endotoxin level (17)

Biologically Active

Biologically active (11)

Animal-free

Animal-free (1)

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Rat NOG / Noggin Protein (Recombinant His-GST, N-terminus) (Gly1-Trp117) - LS-G14800

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

40.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human NOG / Noggin Protein (Recombinant) - LS-G77

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

46 kDa

Price:

5 µg/$268; 20 µg/$349

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Mouse NOG / Noggin Protein (Recombinant) - LS-G247

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

46.4 kDa

Price:

5 µg/$268; 20 µg/$349

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Mouse NOG / Noggin Protein (Recombinant) - LS-G3701

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

Price:

5 µg/$281; 20 µg/$369

• Unmodified
• Animal-free

• Unmodified
• Animal-free

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Human NOG / Noggin Protein (Recombinant) (aa28-232) - LS-G5843

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

46.3 kDa

Price:

5 µg/$282; 100 µg/$1,186; 500 µg/$2,269

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Human NOG / Noggin Protein (Recombinant GST) (Full Length) - LS-G31545

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.29 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NOG / Noggin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89374

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.81 kDa

Price:

20 µg/$150

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Mouse NOG / Noggin Protein (Recombinant 6His, C-terminus) (Gln28-Cys232) - LS-G55652

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

23.9kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,377; 1 mg/$1,765

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Human NOG / Noggin Protein (Recombinant Fc) (Met1-Cys232) - LS-G97724

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.8 kDa

Price:

100 µg/$556

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NOG / Noggin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100557

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.81 kDa

Price:

100 µg/$494

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Human NOG / Noggin Protein (Recombinant) - LS-G131299

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~23 kDa

Price:

20 µg/$395; 1 mg/$6,427

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Human NOG / Noggin Protein (Recombinant Fc, C-terminus) - LS-G138994

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.2 kDa

Price:

10 µg/$265; 50 µg/$368

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Human NOG / Noggin Protein (Recombinant) - LS-G137472

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein.

Molecular Weight:

Recombinant human Noggin is a 46 kD disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28 - 33 kD by SDS PAGE analysis under reducing cond

Price:

5 µg/$272; 20 µg/$352

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Mouse NOG / Noggin Protein (Recombinant) - LS-G137476

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein.

Molecular Weight:

Recombinant Mouse Noggin is a 46.4 kD disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. The predicted N-terminal amino acid is Met.

Price:

5 µg/$272; 20 µg/$352

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Human NOG / Noggin Protein (Recombinant) (Gln28-Cys232) - LS-G139798

Source:

Mammalian Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

23 kDa

Price:

10 µg/$288; 50 µg/$436

Select

Human NOG / Noggin Protein (Recombinant His,C-terminus) (Met1-Cys232) - LS-G138354

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

24.6 kDa

Price:

100 µg/$907; 1 mg/$4,801

Select

Mouse NOG / Noggin Protein (Recombinant His,C-terminus) (Gln28-Cys232) - LS-G139379

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

23.9 kDa

Price:

10 µg/$277; 50 µg/$389

Select

Mouse NOG / Noggin Protein (Recombinant) - LS-G131527

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

20 µg/$432

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Rat NOG / Noggin Protein (Native His-MBP, N-terminus) - LS-G133756

Source:

Rat

Tag:

His-MBP, N-terminus

Molecular Weight:

64kDa

Price:

10 µg/$294; 50 µg/$522; 200 µg/$1,034; 100 µg/$832; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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Rat NOG / Noggin Protein (Recombinant His-GST, N-terminus) - LS-G132832

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

44kDa

Price:

10 µg/$315; 50 µg/$655; 200 µg/$1,233; 100 µg/$1,038; 1 mg/$2,476; 500 µg/$1,978; 5 mg/$4,579; 2 mg/$2,669

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Human NOG / Noggin Protein (Recombinant His) (aa28-232) - LS-G140954

Source:

E. coli

Sequence Length:

204 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

22.55 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human NOG / Noggin Protein (Recombinant) - LS-G27145

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

29-31 kDa (SDS-PAGE)

Price:

50 µg/$401; 10 µg/$278

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Mouse NOG / Noggin Protein (Recombinant) - LS-G27138

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

29-31 kDa (SDS-PAGE)

Price:

5 µg/$253; 25 µg/$304

Select

Human NOG / Noggin Protein (Recombinant) - LS-G145556

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

57 kDa

Price:

1 mg/$1,612; 50 µg/$300

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Dog NOG / Noggin Protein (Recombinant His) (aa28-240) - LS-G14787

Source:

E. coli

Tag:

His

Molecular Weight:

25.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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