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Nkx 2.5 is a lineage restricted transcription factor that regulates the expression of heart specific genes. This regulation is essential for tissue differentiation and the determination of temporal and spatial patterns of development. Abundant expression of Nkx 2.5 is observed in the mouse heart from the time of cardiac differentiation through adult life. Targeted disruption of Nkx 2.5 in mice results in early embryonic lethality with cardiac development arrested at the linear tube stage, prior to looping.
Gene Name: | NK2 homeobox 5 |
Synonyms: | NKX2-5, Cardiac-specific homeo box, Cardiac-specific homeobox 1, Cardiac-specific homeobox, CSX1, CHNG5, HLHS2, NKX2E, NKX4-1, NKX2.5, Tinman paralog, VSD3, CSX, Homeobox protein CSX, Homeobox protein Nkx-2.5, NK2 homeobox 5 |
Target Sequences: | NM_004387 NP_004378.1 P52952 |
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