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NCAM / CD56

neural cell adhesion molecule 1

NCAM / CD56 is a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants.

Gene Name: neural cell adhesion molecule 1
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: NCAM1, CD56, CD56 antigen, MSK39, NCAM-1, N-CAM-1, NCAM
Target Sequences: NM_000615 NP_000606.3 P13591

Publications (6)

1
Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. Grabrucker AM, Garner CC, Boeckers TM, Bondioli L, Ruozi B, Forni F, Vandelli MA, Tosi G. PloS one. 2011 6:e17851. (Flo; Human) [Full Text Article] [PubMed:21448455] [PMC:PMC3063171]
2
Molecular clock regulates daily a1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons. Kondoh D, Tateno H, Hirabayashi J, Yasumoto Y, Nakao R, Oishi K. The Journal of biological chemistry. 2014 289:36158-65. (IP; Human) [Full Text Article] [PubMed:25384980] [PMC:PMC4276879]
3
Schwann cells induce cancer cell dispersion and invasion. Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara WF, Chernichenko N, Lee SY, Barajas F, Chen CH, Bakst RL, Vakiani E, He S, Hall A, Wong RJ. The Journal of clinical investigation. 2016 126:1538-54. (IF; Human) [Full Text Article] [PubMed:26999607] [PMC:PMC4811155] Related Antibodies: LS-B5569.
4
Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression. Jiang LN, Liu YB, Li BH. Asian journal of andrology. 2018 September; [Full Text Article] [PubMed:30198495] [PMC:PMC6337959] Related Antibodies: LS-C5374.
5
Cellular and morphological changes with EAA supplementation before and after total knee arthroplasty. Jonathan B Muyskens, Douglas M Foote, Nathan J Bigot, Lisa A Strycker, Keith Smolkowski, Tessa K Kirkpatrick, Brick A Lantz, Steven N Shah, Craig G Mohler, Brian A Jewett, Erin C Owen, Hans C Dreyer. Journal of applied physiology (Bethesda, Md. : 1985). 2019 August;127:531-545. [Full Text Article] [PubMed:31343947] [PMC:PMC6732445] Related Antibodies: LS-C134863.
6
Generation of an induced pluripotent stem cell line carrying a biallelic deletion (SCTCi019-A) in GCDH using CRISPR/Cas9. Imke M E Schuurmans, Ka M Wu, Clara D M van Karnebeek, Nael Nadif Kasri, Alejandro Garanto. Stem cell research. 2023 June;69:103069. [Full Text Article] [PubMed:36947993] Related Antibodies: LS-C171208.
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Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
NCAM / CD56 (12)
No (12)
10His, N-terminus + Myc, C-terminus (1)
6His, C-terminus (2)
6His, N-terminus (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His,C-terminus (1)
Mouse IgG2a Fc, N-terminus (1)
Myc-DDK (Flag) (3)
Human (9)
Rat (2)
293T Cells (1)
E. coli (3)
HEK 293 Cells (4)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (5)
Biologically active (1)
NCAM / CD56 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
NCAM / CD56 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
75.9 kDa
100 µg/$500; 20 µg/$364; 1 mg/$1,679
NCAM / CD56 Protein - Recombinant Neural Cell Adhesion Molecule By SDS-PAGE
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E. coli
His, N-Terminal
33.3 kDa
10 µg/$261; 50 µg/$336; 200 µg/$630; 1 mg/$1,602; 5 mg/$2,538; 2 mg/$1,774
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
65.5kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
NCAM / CD56 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NCAM / CD56 Protein - Purified recombinant protein NCAM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
94.4 kDa
20 µg/$1,107
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
79.2 kDa
50 µg/$483
NCAM / CD56 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
94.4 kDa
20 µg/$150
NCAM / CD56 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
94.4 kDa
100 µg/$494
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HEK 293 Cells
Mouse IgG2a Fc, N-terminus
Biologically active
Less than 5.0 EU/mg protein (determined by LAL method).
~140 kDa (SDS-PAGE)
50 µg/$442
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HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
66.1 kDa
100 µg/$721
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
65.5 kDa
10 µg/$281; 50 µg/$389
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).