Human NCAM / CD56

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

MOC-1

Unconjugated

Tissue culture supernatant

Concentrated

MOC-1 detects an isoform of the neural cell adhesion molecule (NCAM) expressed on natural killer (NK) cells of approximately 145 kD. NK cells make up approximately 10%-25% of peripheral blood lymphocytes, In addition, NCAM is expressed on a variety of neural tissues and some tumors of neuron-endocrine origin, such as small cell lung cancer (SCLC). The CD56 antigen is not expressed on other immune cells. NK cells form a distinct subpopulation of lymphocytes, which are capable of performing their cytotoxic activity without MHC restriction. Target cells may include virally infected cells or transformed cells and CD56 appears to be involved in the cytotoxic activity of NK cells. Certain subtypes of T cell lymphomas may express the CD56 antigen. These include peripheral T cell lymphoma (NK cell lymphoma: CD56+, EBV+) and T lymphocytic lymphoma (CD56+/-).

• IHC
• IHC - Frozen
• Flow Cytometry

CD56 (MOC-1) can be applied in flow cytometry for analysis of blood samples and in immunohistochemistry using frozen sections and bone marrow aspirates. CD56 is applied in flow cytometry for the detection of NK cells in immune monitoring. In addition, the neoplastic counterpart of the NK cell can be characterized as T gamma lymphocytosis, showing expression of a number of antigens, e. g. CD56+, CD7+, CD16+, CD2+/- and CD8+/-. Co-expression of CD56 and CD138 )B-B4) is an indication of plasma cell malignancy in multiple myeloma, although it does not occur in all samples. In lung tumors, MOC-1 antibody is helpful in discriminating SCLC from non SCLC. The antibody is effectiveness formulated for direct immunofluorescent staining of human tissue for flow cytometric analysis using 10 ul/106 leukocytes. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

Sodium Azide, BSA

Store at 2-8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P13591 NCBI: NM_000615 NP_000606.3