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MUC5B

mucin 5B, oligomeric mucus/gel-forming

MUC5B is a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.

Gene Name: mucin 5B, oligomeric mucus/gel-forming
Synonyms: MUC5B, MUC-5B, MUC9, Mucin-5B, Sublingual gland mucin, MG1, Cervical mucin, Cervical mucin MUC5B, MUC5
Target Sequences: NM_002458 NP_002449.2 Q9HC84

Publications (4)

1
Vagal sensory neurons drive mucous cell metaplasia. Sébastien Talbot, Benjamin Doyle, Junwei Huang, Jo-Chiao Wang, Maryam Ahmadi, David P Roberson, Ajay Yekkirala, Simmie L Foster, Liam E Browne, Bruce P Bean, Bruce D Levy, Clifford J Woolf. The Journal of allergy and clinical immunology. 2020 June;145:1693-1696.e4. [Full Text Article] [PubMed:31954778]
2
Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach. Tessa Y S Le Large , Laura L Meijer , Rosita Paleckyte, Lenka N C Boyd, Bart Kok, Thomas Wurdinger, Tim Schelfhorst, Sander R Piersma, Thang V Pham, Nicole C T van Grieken, Barbara M Zonderhuis, Freek Daams, Hanneke W M van Laarhoven, Maarten F Bijlsma, Connie R Jimenez, Elisa Giovannetti , Geert Kazemier. The oncologist. 2020 Apr;25:e634-e643. [Full Text Article] [PubMed:31943574] [PMC:PMC7160420]
3
Quantification of very late xerostomia in head and neck cancer patients after irradiation. Grace C Blitzer, Nicole M Rogus-Pulia, Cristina Paz, Kwangok P Nickel, Vanessa L Cannaday, Cynthia A Kelm-Nelson, Sailendharan Sudakaran, Richard J Chappell, Tiffany Glazer, Randall J Kimple. Laryngoscope investigative otolaryngology. 2022 August;7:1018-1024. [Full Text Article] [PubMed:36000048] [PMC:PMC9392383]
4
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. Yan Shin J Liao, Shin Ping Kuan, Maria V Guevara, Emily N Collins, Kalina R Atanasova, Joshua S Dadural, Kevin Vogt, Veronica Schurmann, Laura Bravo, Eda Eken, Mariana Sponchiado, Leah R Reznikov. American journal of physiology. Lung cellular and molecular physiology. 2020 May;318:L873-L887. [Full Text Article] [PubMed:32160007] [PMC:PMC7272746]
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MUC5B Antibody - Immunohistochemical analysis of paraffin-embedded rectum tissues using MUC5B mouse mAb with DAB staining.
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MUC5B Mouse anti-Human Monoclonal (7F5A1) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$459
MUC5B Antibody
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MUC5B Rabbit anti-Mouse Polyclonal (aa75-295) Antibody
Mouse
WB
Unconjugated
100 µl/$291; 200 µl/$326; 500 µl/$441; 1 ml/$499; 2 ml/$622; 5 ml/$1,067
MUC5B Antibody - Western blot of recombinant MUC5B.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MUC5B Rabbit anti-Human Polyclonal (aa5366-5444) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
MUC5B Antibody - Western blot of recombinant MUC5B.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MUC5B Rabbit anti-Human Polyclonal (aa5366-5444) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
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MUC5B Mouse anti-Human Monoclonal (N-Terminus) (5B19-2E) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$842
MUC5B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
MUC5B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$705
MUC5B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Biological Fluids, Plasma, Serum, Tissue Homogenates
1 Plate/$669
MUC5B ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
MUC5B ELISA Kit
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Sandwich
96-Well Microplate
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MUC5B ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$863
MUC5B ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
MUC5B Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MUC5B Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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MUC5B Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µl/$305; 200 µl/$345; 500 µl/$479; 1 ml/$547; 2 ml/$725; 5 ml/$1,192
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E. coli
6His, N-terminus
12.3 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
MUC5B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$897
MUC5B Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using MUC5B Polyclonal Antibody at dilution of 1:70.
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MUC5B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MUC5B Antibody - Goat Anti-Muc5b (mouse) Antibody Immunofluorescence analysis of paraformaldehyde fixed NIH3T3 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing vesicle staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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MUC5B Goat anti-Mouse Polyclonal (aa4756-4766) Antibody
Mouse
Peptide-ELISA
Unconjugated
100 µg/$503
MUC5B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
MUC5B ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
54.9 - 40000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$851
MUC5B ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
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MUC5B Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µg/$357
MUC5B Antibody - Western Blot; Sample: Recombinant MUC5B, Rat.
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MUC5B Rabbit anti-Rat Polyclonal (aa898-1002) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
MUC5B ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,109; 1000 Wells/$1,625
MUC5B Protein - Recombinant Mucin 5 Subtype B By SDS-PAGE
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E. coli
His
24.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Viewing 1-25 of 104 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).