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MUC5AC has been isolated from airway secretions. It is found in the protective film of mucus coating the mucosal surfaces of the respiratory tract and the normal gastrointestinal tissues. Mucins are also expressed at low levels in human fetal gut. MUC5AC is involved in epithelial cell proliferation and differentiation in adult airway mucosa and can be used as a marker for hypersecretory disorders. MUC5AC has also been observed in various tumors. For instance it is expressed in primary mucinous ovarian tumors but not in colonic carcinoma metastatic to the ovary, which makes it a useful marker to distinguish the two types of cancer.
Gene Name: | mucin 5AC, oligomeric mucus/gel-forming |
Synonyms: | MUC5AC, Gastric mucin, Major airway glycoprotein, Muc5/5ac, Mucin-5AC, LeB, Lewis B blood group antigen, Tracheobronchial mucin, TBM, MUC-5AC, MUC5 |
Target Sequences: | AJ001403 CAA04738.1 P98088 |
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