MSLN / Mesothelin

mesothelin

This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. Mesothelin null mutant mice show a normal phenotype suggesting that mesothelin function is not essential for growth or reproduction in mice (Bera et al., 2000).

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Products

Proteins (37)

Type

Over-Expression Lysate (6)

Recombinant (31)

Target

MSLN / Mesothelin (37)

Application

SDS-PAGE (5)

Publications

No (37)

Tag

6His, C-terminus (6)

6His, N-terminus (1)

Fc (2)

Fc, C-terminus (4)

GST (1)

GST, N-terminus (1)

His (2)

His,C-terminus (2)

His-AVI, C-terminus (1)

His-GST (1)

His-GST, N-terminus (1)

His-SUMO (1)

Human IgG Fc, C-terminus (1)

Human IgG1 Fc, N-terminus (2)

Myc-DDK (Flag) (7)

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Species

Human (29)

Mouse (5)

Source

293T Cells (3)

CHO Cells (2)

E. coli (4)

HEK 293 Cells (12)

Human Cells (7)

Mammalian Cells (6)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (21)

Biologically Active

Biologically active (3)

Select

Human MSLN / Mesothelin Protein (Recombinant 6His, C-terminus) (Glu296-Ser598) - LS-G40289

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.9kD

Price:

10 µg/$266; 50 µg/$321; 500 µg/$905; 1 mg/$1,369

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Human MSLN / Mesothelin Protein (Recombinant Fc, C-terminus) (Glu296-Ser598) - LS-G40290

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

61kD

Price:

10 µg/$277; 50 µg/$386; 500 µg/$1,533; 1 mg/$2,055

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Human MSLN / Mesothelin Protein (Recombinant GST) (Full Length) - LS-G32032

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

94.3 kDa

Price:

2 µg/$439

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Human MSLN / Mesothelin Protein (Recombinant Fc) (Glu296-Gly580) - LS-G97707

Source:

HEK 293 Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

60.7 kDa

Price:

100 µg/$721

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Human MSLN / Mesothelin Protein (Recombinant His-GST, N-terminus) (Glu400-Leu615) - LS-G15920

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

55.7 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Human MSLN / Mesothelin Protein (Recombinant Human IgG1 Fc, N-terminus) (Glu296-Gly580) - LS-G50724

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human MSLN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 545 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

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Human MSLN / Mesothelin Protein (Recombinant 6His, C-terminus) - LS-G145956

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.9 kDa

Price:

50 µg/$357

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Human MSLN / Mesothelin Protein (Recombinant 6His, N-terminus) (Pro291-Asp590) - LS-G26347

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

33 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human MSLN / Mesothelin Protein (Recombinant 6His, C-terminus) (Leu37-Arg286) - LS-G40198

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

27.8kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765

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Human MSLN / Mesothelin Protein (Recombinant) (Glu296-Gly580) - LS-G50728

Source:

HEK 293 Cells

Tag:

None

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human MSLN consists 287 amino acids and predicts a molecular mass of 32.4 kDa. The apparent molecular mass of the protein is higher than the theoretical value in SDS-PAGE under reducing conditions due to glycosylation.

Price:

50 µg/$348; 500 µg/$1,343

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Mouse MSLN / Mesothelin Protein (Recombinant 6His, C-terminus) - LS-G137732

Source:

HEK 293 Cells

Tag:

6His, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 291 amino acid recombinant protein has a predicted molecular mass of approximately 32.9 kD. The DTT-reduced and non-reduced protein migrate at approximately at 50kD by SDS-PAGE. The N-terminal amino acid is Asp.

Price:

10 µg/$306; 25 µg/$375; 100 µg/$731; 500 µg/$1,723

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Human MSLN / Mesothelin Protein (Recombinant Fc, C-terminus) (Leu37-Arg286) - LS-G40196

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.9kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765

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Human MSLN / Mesothelin Protein (Recombinant GST, N-terminus) (aa464-563) - LS-G61428

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MSLN / Mesothelin Protein (Recombinant Human IgG1 Fc, N-terminus) (Glu296-Gly580) - LS-G50725

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human MSLN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 545 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Price:

20 µg/$364; 100 µg/$595

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Human MSLN / Mesothelin Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Arg286) - LS-G50726

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human MSLN/Fc comprises 491 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$2,003

Select

Human MSLN / Mesothelin Protein (Recombinant His,C-terminus) (Met1-Arg286) - LS-G50727

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human MSLN consists of 261 amino acids and predicts a molecular mass of 28.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$2,003

Select

Human MSLN / Mesothelin Protein (Recombinant Fc) (Met1-Arg286) - LS-G97706

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.7 kDa

Price:

100 µg/$721

Select

Human MSLN / Mesothelin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66270

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.7 kDa

Price:

20 µg/$1,107

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MSLN / Mesothelin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127046

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.99 kDa

Price:

100 µg/$494

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MSLN / Mesothelin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114269

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.99 kDa

Price:

100 µg/$710

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MSLN / Mesothelin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100652

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.91 kDa

Price:

100 µg/$494

Select

Human MSLN / Mesothelin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77321

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.91 kDa

Price:

20 µg/$150

Select

Human MSLN / Mesothelin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77323

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.99 kDa

Price:

20 µg/$215

Select

Human MSLN / Mesothelin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77325

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.99 kDa

Price:

20 µg/$150

Select

Human MSLN / Mesothelin Protein (Recombinant) - LS-G137753

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 553 amino acid recombinant protein has a predicted molecular mass of approximately 61.2 kD. The DTT-reduced and non-reduced protein migrate at approximately 70 kD and 150 kD by SDS-PAGE respectively. The N-terminal amino acid is Ser.

Price:

10 µg/$264; 25 µg/$302; 100 µg/$413

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