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MPZL1
Myelin Protein Zero-like 1
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
| Gene Name: | Myelin Protein Zero-like 1 |
| Synonyms: | MPZL1, Myelin protein zero-like 1, MPZL1b, Protein zero-related, PZR, PZR1b, PZRa, PZRb, Protein zero related |
| Target Sequences: | NM_003953 NP_003944.1 O95297 |
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