Target
Human MPZL1
Synonyms
MPZL1 | Myelin protein zero-like 1 | MPZL1b | Protein zero-related | PZR | PZR1b | PZRa | PZRb | Protein zero related
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant human Myelin protein zero-like protein 1 protein (195-258AA)
Specificity
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.