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MPO / Myeloperoxidase
myeloperoxidase
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains (12 kD) and 2 heavy chains (60 kD). This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. It is released in a degranulation process in response to bursts of oxygen consumption, which also forms H2O2. MPO and H2O2 form a complex that oxidases a large variety of substances some of which have microbicidal effects. The gene for MPO is translocated in patients with acute promyelocytic leukemia and is mutated in hereditary MPO deficiency.
| Gene Name: | myeloperoxidase |
| Synonyms: | MPO, Myeloperoxidase precursor, Myeloperoxidase |
| Target Sequences: | NM_000250 NP_000241.1 P05164 |
Publications (7)
1
The glycosylation of myeloperoxidase. Ravnsborg T, Houen G, Hjrup P. Biochimica et biophysica acta. 2010 1804:2046-53. (ELISA; Human)
[PubMed:20621206]
2
Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. Sun Q, Zhong W, Zhang W, Zhou Z. American journal of physiology. Gastrointestinal and liver physiology. 2016 310:G205-14. (IHC; Human)
[Full Text Article]
[PubMed:26585415]
[PMC:PMC4971814]
3
Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. Iracheta-Vellve A, Petrasek J, Gyogyosi B, Bala S, Csak T, Kodys K, Szabo G. Liver international : official journal of the International Association for the Study of the Liver. 2017 July;37:968-973. [Full Text Article]
[PubMed:28345165]
[PMC:PMC5479767]
☰ Filters
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Antibodies
(188)
Type
Primary
(188)
Target
MPO / Myeloperoxidase
(188)
Reactivity
Human
(148)
Mouse
(41)
Rat
(28)
Bovine
(16)
Cow
(16)
Hamster
(2)
Horse
(1)
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(1)
Application
IHC
(40)
IHC-Fr
(17)
IHC-P
(18)
WB
(149)
Flo
(28)
ELISA
(76)
ICC
(18)
IE
(1)
IF
(5)
IP
(27)
Peptide-ELISA
(2)
Host
rabbit
(105)
mouse
(81)
goat
(1)
human
(1)
Product Group
IHCPlus
(3)
PathPlus Cancer
(2)
PathPlus Cancer Pathology
(2)
Isotype
Ig
(1)
IgG
(57)
IgG1
(41)
IgG2a
(3)
IgG2b
(14)
IgG2b,k
(3)
Clonality
monoclonal mc
(81)
polyclonal pc
(107)
Clone
16E3
(1)
16G6
(1)
17G2
(1)
18B7
(1)
19G8
(1)
19H2
(1)
266-6K1
(5)
2A11
(1)
2C7
(4)
2D4
(2)
3E11
(1)
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(3)
4B3
(1)
59A5
(2)
7F5A2
(1)
8E6
(3)
8F4
(4)
9B12G7
(1)
9B12G7,4D8B12,9B12D9,9C11A5
(1)
B7
(3)
MPO421-8B2
(3)
Format
AP Conjugated
(1)
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(7)
APC Conjugated
(12)
Azide-free
(3)
Biotin Conjugated
(20)
Concentrated
(4)
Cy3 Conjugated
(7)
Cy7 Conjugated
(7)
FITC Conjugated
(21)
HRP Conjugated
(19)
Magnetic beads Conjugated
(1)
PE Conjugated
(15)
Ready-to-Use
(1)
RPE Conjugated
(1)
Sepharose Conjugated
(1)
Unconjugated
(83)
Epitope
aa165-278
(18)
aa134-263
(8)
aa139-252
(8)
aa253-718
(8)
aa420-448
(7)
aa548-575
(7)
aa60-89
(7)
C-Terminus
(4)
Internal
(2)
40-120 aa, N-terminal
(1)
41-90 aa, N-terminal
(1)
Amino Acid: 1-193
(1)
N-Terminus
(1)
aa406-745
(1)
aa714-728
(1)
aa74-86
(1)
Publications
No
(187)
Yes
(1)
Cancer Pathology
Cancer
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (3E11) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Cancer Pathology
Cancer
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (9B12G7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$775
MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (FITC) (8F4) Antibody
Mouse
Flo, IHC, IHC-Fr
FITC Conjugated
100 µg/$807
MPO / Myeloperoxidase Human anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
2 ml/$467
MPO / Myeloperoxidase Rabbit anti-Mouse Polyclonal (aa253-718) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (FITC) (2D4) Antibody
Mouse, Rat
Flo
FITC Conjugated
100 µg/$863
MPO / Myeloperoxidase Rabbit anti-Mouse Polyclonal (aa139-252) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal (aa714-728) Antibody
Hamster, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$460
MPO / Myeloperoxidase Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$460
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
1 ml/$505
MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (8F4) Antibody
Mouse, Rat
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$723
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (4A4) Antibody
Human
ELISA
Unconjugated
1 mg/$973
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (Concentrated) (HRP) (2C7) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
HRP Conjugated, Concentrated
0.2 mg/$735
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
100 µl/$393
MPO / Myeloperoxidase Goat anti-Human Polyclonal (aa74-86) Antibody
Rabbit, Hamster, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (266-6K1) Antibody
Human
WB
Unconjugated
100 µg/$771
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (FITC) (2C7) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (2C7) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P
Unconjugated
20 µg/$281; 0.2 mg/$471
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal (C-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
MPO / Myeloperoxidase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$564
MPO / Myeloperoxidase Mouse anti-Mouse Monoclonal (Concentrated) (HRP) (8F4) Antibody
Mouse
Flo, IHC, IHC-Fr
HRP Conjugated, Concentrated
1 ml/$857
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (MPO421-8B2) Antibody
Human
ELISA, Flo
Unconjugated
0.1 mg/$330
MPO / Myeloperoxidase Mouse anti-Human Monoclonal (FITC) (MPO421-8B2) Antibody
Human
ELISA, Flo
FITC Conjugated
100 Tests/$337
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product results
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