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Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Gene Name: | mediator complex subunit 12 |
Synonyms: | MED12, ARC240, CAG repeat protein 45, CAGH45, FG syndrome 1, Hypothetical protein kiaa0192, FGS1, Mediator complex subunit 12, Putative mediator subunit 12, MED12S, TNRC11, TRAP230, HOPA, Human opposite paired, KIAA0192, OKS, OPA-containing protein |
Target Sequences: | NM_005120 NP_005111.2 Q93074 |
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