Target
Human MED12
Synonyms
MED12 | ARC240 | CAG repeat protein 45 | CAGH45 | FG syndrome 1 | Hypothetical protein kiaa0192 | FGS1 | Mediator complex subunit 12 | Putative mediator subunit 12 | MED12S | TNRC11 | TRAP230 | HOPA | Human opposite paired | KIAA0192 | OKS | OPA-containing protein
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
FITC,
Biotin.
Immunogen
Recombinant human Mediator of RNA polymerase II transcription subunit 12 protein (1742-2011AA)
Specificity
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.