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Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Gene Name: | minichromosome maintenance complex component 7 |
Synonyms: | MCM7, CDC47 homolog, CDC47, Homolog of S. cerevisiae Cdc47, p1.1-MCM3, p1CDC47, p85MCM, PNAS146 |
Target Sequences: | NM_005916 NP_005907.3 P33993 |
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