MAP3K5 / ASK1

mitogen-activated protein kinase kinase kinase 5

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

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Products

ELISA Kits (16)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

Sandwich (10)

Sandwich CLIA (1)

Target

MAP3K5 / ASK1 (16)

Reactivity

Human (8)

Mouse (6)

Rat (2)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (5)

96-Well Strip Plate (10)

Publications

No (16)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (1)

Plasma (6)

Serum (6)

Tissue Homogenates (3)

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Mouse/Human/Rat Phospho-MAP3K5 / ASK1 (Ser966) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1451

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human Phospho-MAP3K5 / ASK1 (Ser83) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1450

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F4572

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Mouse/Human/Rat MAP3K5 / ASK1 (Cell-Based ELISA) ELISA Kit - LS-F1806

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human MAP3K5 / ASK1 (Custom ELISA) ELISA Kit - LS-F17012

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse MAP3K5 / ASK1 (Custom ELISA) ELISA Kit - LS-F17013

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F23034

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F21945

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F26639

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Mouse MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F36288

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F37056

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse MAP3K5 / ASK1 (CLIA) ELISA Kit - LS-F30499

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

7.813 - 500 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Chicken MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F41402

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F41404

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F41405

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit MAP3K5 / ASK1 (Sandwich ELISA) ELISA Kit - LS-F41406

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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