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MAGEA1 / MAGE 1

melanoma antigen family A, 1 (directs expression of antigen MZ2-E)

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. MAGE was originally isolated from human melanoma cells as an antigen that is recognizes by cytolytic T lymphocytes. It has since been documented in other carcinomas. In addition, expression has been documented in highly proliferating germ cells.

Gene Name: melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
Synonyms: MAGEA1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen, MAGE1A, Melanoma antigen family A 1, Melanoma antigen MAGE-1, MAGE 1, MAGE1, Melanoma-associated antigen 1
Target Sequences: NM_004988 NP_004979.3 P43355

Publications (2)

1
Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Planells-Palop V, Hazazi A, Feichtinger J, Jezkova J, Thallinger G, Alsiwiehri NO, Almutairi M, Parry L, Wakeman JA, McFarlane RJ. Molecular cancer. 2017 16:84. (ICC, IHC-P; Human) [Full Text Article] [PubMed:28446200] [PMC:PMC5406905]
2
Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. Kenji Murata , Munehide Nakatsugawa , Muhammed A Rahman, Linh T Nguyen, Douglas G Millar, David T Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Brian D Burt, Dalam Ly, Kayoko Saso, Alexandra Easson, David P Goldstein, Michael Reedijk, Danny Ghazarian, Trevor J Pugh, Marcus O Butler, Tak W Mak, Pamela S Ohashi, Naoto Hirano. eLife. 2020 Apr;9:e53244. [Full Text Article] [PubMed:32314731] [PMC:PMC7234812] Related Antibodies: LS-C391567.

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
MAGEA1 / MAGE 1 (9)
No (9)
6His, N-terminus (1)
DDK,C-terminus (1)
GST (2)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (3)
Yeast (1)
Purified (4)
MAGEA1 / MAGE 1 Protein
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Yeast
6His, N-terminus
36.31 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
MAGEA1 / MAGE 1 Protein - 12.5% SDS-PAGE of human MAGEA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
59.73 kDa
10 µg/$479; 25 µg/$670
MAGEA1 / MAGE 1 Protein - 12.5% SDS-PAGE of human MAGEA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.39 kDa
10 µg/$479; 25 µg/$670
MAGEA1 / MAGE 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$150
MAGEA1 / MAGE 1 Protein - Purified recombinant protein MAGEA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$1,107
MAGEA1 / MAGE 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
100 µg/$494
MAGEA1 / MAGE 1 Protein - Recombinant Melanoma Antigen Family A1 (MAGEA1) by SDS-PAGE
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E. coli
His, N-Terminal
27.4kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
MAGEA1 / MAGE 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
DDK,C-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).