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LIMK2

LIM domain kinase 2

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

Gene Name: LIM domain kinase 2
Family/Subfamily: Protein Kinase , LIMK
Synonyms: LIMK2, LIM domain kinase 2, LIM kinase 2, LIMK-2
Target Sequences: NM_016733 NP_057952.1 P53671

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Products
Antibodies (45)
Primary (45)
LIMK2 (45)
Human (44)
Mouse (36)
Rat (26)
Bat (1)
Bovine (1)
Chicken (1)
Dog (1)
Horse (2)
Monkey (2)
Pig (1)
Rabbit (1)
Zebrafish (1)
IHC (24)
IHC-P (11)
WB (42)
ELISA (10)
ICC (3)
IF (10)
Peptide-ELISA (9)
rabbit (42)
mouse (1)
goat (1)
sheep (1)
IgG (34)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (44)
2H2-E11 (1)
APC Conjugated (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (40)
pThr505 (7)
pSer283 (4)
220-300 aa (2)
Internal (2)
pSer291/Ser293 (2)
Asp499 (1)
Lys491 (1)
aa1-240 (1)
aa1-252 (1)
aa181-193 (1)
aa227-276 (1)
aa249-298 (1)
aa294-655 (1)
aa461-510 (1)
aa471-520 (1)
aa570-599 (1)
aa596-635 (1)
p505 (1)
No (45)
LIMK2 Antibody - Western blot analysis of lysates from NIH/3T3 cells, treated with PMA 125ng/ml 30', using LIMK2 Antibody. The lane on the right is blocked with the synthesized peptide.
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LIMK2 Rabbit anti-Human Polyclonal (aa249-298) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
LIMK2 Antibody - Immunohistochemical analysis of LIMK2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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LIMK2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
LIMK2 Antibody - 1:200 staining human pancreas tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LIMK2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human heart tissue using LIMK2 antibody.
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LIMK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
LIMK2 Antibody - Immunohistochemistry analysis of paraffin-embedded human heart tissue, using LIMK2 Antibody. The picture on the right is blocked with the synthesized peptide.
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LIMK2 Rabbit anti-Human Polyclonal (aa461-510) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
LIMK2 Antibody - Western blot of Phospho-LIMK-2 (T505) antibody
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LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LIMK2 Antibody - IHC of paraffin-embedded Breast ca using LIM kinase 2 antibody at 1:250 dilution.
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LIMK2 Rabbit anti-Human Polyclonal (aa1-252) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
LIMK2 Antibody - IHC of paraffin-embedded CA922 xenograft using LIM kinase 2 antibody at 1:500 dilution.
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LIMK2 Rabbit anti-Human Polyclonal (aa294-655) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
LIMK2 Antibody - IHC of p-LIMK2 (T505) pAb in paraffin-embedded human breast carcinoma tissue.
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LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
LIMK2 Antibody - IHC of LIMK2 (K491) pAb in paraffin-embedded human brain tissue.
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LIMK2 Rabbit anti-Human Polyclonal (Lys491) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
LIMK2 Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Select
LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody
IF, IHC, WB
Unconjugated
100 µl/$431
LIMK2 Antibody - Immunofluorescence of monoclonal antibody to LIMK2 on HeLa cell . [antibody concentration 10 ug/ml]
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LIMK2 Mouse anti-Human Monoclonal (2H2-E11) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
LIMK2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using LIMK2 (Phospho-Thr505) Antibody. The picture on the right is blocked with the phospho peptide.
Select
LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
LIMK2 Rabbit anti-Human Polyclonal (220-300 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LIMK2 Antibody - P-Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using LIMK2 (phospho-Thr505) antibody.
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LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
LIMK2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Select
LIMK2 Rabbit anti-Human Polyclonal (aa1-240) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
LIMK2 Antibody - Staining NIH-3T3 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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LIMK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LIMK2 Antibody - Immunohistochemical of paraffin-embedded H.kidney section using LIMK2 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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LIMK2 Rabbit anti-Human Polyclonal (aa570-599) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
LIMK2 Rabbit anti-Human Polyclonal (pThr505) Antibody
Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Rat, Human, Monkey
IHC, WB
Unconjugated
50 µg/$489
Select
LIMK2 Rabbit anti-Human Polyclonal (pSer291/Ser293) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
Select
LIMK2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
LIMK2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using LIMK2 (Phospho-Ser283) Antibody. The picture on the right is blocked with the phospho peptide.
Select
LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Select
LIMK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
LIMK2 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using LIMK2 (Phospho-Ser283) antibody.
Select
LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µg/$357
LIMK2 Antibody - Western blot of LIMK2 phosphorylation expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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LIMK2 Rabbit anti-Human Polyclonal (pSer283) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
Viewing 1-25 of 45 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).