LIMK1 / LIMK

LIM domain kinase 1

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

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Products

Antibodies (86)

Type

Primary (86)

Target

LIMK1 / LIMK (86)

Reactivity

Human (83)

Mouse (39)

Rat (30)

Chicken (2)

Chimpanzee (1)

Dog (4)

Horse (2)

Monkey (4)

Orangutan (1)

Rabbit (2)

Xenopus (2)

Zebrafish (2)

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Application

IHC (37)

IHC-P (15)

WB (71)

Flo (18)

DB (7)

ELISA (31)

ICC (1)

IF (30)

IP (5)

Peptide-ELISA (7)

Host

rabbit (60)

mouse (26)

Product Group

IHCPlus (3)

Isotype

IgG (48)

IgG1,k (3)

IgG2a (10)

IgG2a,k (2)

IgG2b (10)

Clonality

monoclonal mc (26)

polyclonal pc (60)

Clone

175CT3.2.5 (1)

1A8 (1)

1B2 (1)

2E9 (1)

OTI 7C3 (2)

OTI1F1 (2)

OTI2A11 (2)

OTI3A3 (2)

OTI3G3 (2)

OTI3H6 (2)

OTI6A7 (2)

OTI6B4 (2)

OTI8B2 (2)

OTI8C8 (2)

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Format

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (4)

Carrier-free (10)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Unconjugated (68)

Epitope

pThr508 (18)

aa1-30 (7)

440-520 aa (2)

aa479-508 (2)

Asp502 (1)

C-Terminus (1)

Gln491 (1)

Internal (1)

aa250-300 (1)

aa461-510 (1)

aa471-520 (1)

aa548-648 (1)

aa597-647 (1)

aa599-634 (1)

aa620-647 (1)

p508 (1)

pThr508,pThr505 (1)

pThr508/505 (1)

pTyr507/Thr508/Tyr504/Thr505 (1)

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Publications

No (86)

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IHC-plus™ LIMK1 / LIMK Antibody (clone 1A8) LS-B5430

(4.0) Rating

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (1A8) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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LIMK1 / LIMK Antibody (clone OTI6B4) LS-C173012

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI6B4) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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LIMK1 / LIMK Antibody (clone OTI6B4, Carrier-free) LS-C786090

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI6B4) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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IHC-plus™ LIMK1 / LIMK Antibody (clone 2E9) LS-B5431

(4.0) Rating

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (2E9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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LIMK1 / LIMK Antibody (phospho-Thr508) LS-C826307

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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LIMK1 / LIMK Antibody (aa479-508, clone 175CT3.2.5) LS-C319170

Antibody:

LIMK1 / LIMK Mouse anti-Mouse Monoclonal (aa479-508) (175CT3.2.5) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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LIMK1 / LIMK Antibody (clone OTI8C8) LS-C172997

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI8C8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

LIMK1 / LIMK Antibody (clone OTI8C8, Carrier-free) LS-C786071

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI8C8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

LIMK1 / LIMK Antibody (clone OTI2A11) LS-C173082

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI2A11) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI2A11, Carrier-free) LS-C786181

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI2A11) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

LIMK1 / LIMK Antibody (clone OTI3H6) LS-C172767

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI3H6) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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LIMK1 / LIMK Antibody (clone OTI3H6, Carrier-free) LS-C786004

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI3H6) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

IHC-plus™ LIMK1 / LIMK Antibody (aa597-647) LS-B15073

(4.0) Rating

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (aa597-647) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$485

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LIMK1 / LIMK Antibody (phospho-Thr508,pThr505) LS-C801113

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508,pThr505) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK1 / LIMK Antibody (phospho-Thr508) LS-C801116

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK1 / LIMK Antibody (clone OTI3G3) LS-C172995

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI3G3) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

LIMK1 / LIMK Antibody (clone OTI3G3, Carrier-free) LS-C786069

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (Carrier-free) (OTI3G3) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

LIMK1 / LIMK Antibody (440-520 aa) LS-C380762

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (440-520 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

LIMK1 / LIMK Antibody LS-C801613

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

LIMK1 / LIMK Antibody (phospho-Thr508) LS-C177920

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (pThr508) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

LIMK1 / LIMK Antibody (Gln491) LS-C176780

Antibody:

LIMK1 / LIMK Rabbit anti-Human Polyclonal (Gln491) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

LIMK1 / LIMK Antibody (clone OTI6A7) LS-C172994

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI6A7) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

LIMK1 / LIMK Antibody (clone OTI8B2) LS-C172996

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI8B2) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

LIMK1 / LIMK Antibody (clone OTI1F1) LS-C173111

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI1F1) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

LIMK1 / LIMK Antibody (clone OTI 7C3) LS-C173009

Antibody:

LIMK1 / LIMK Mouse anti-Human Monoclonal (OTI 7C3) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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