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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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LIF

leukemia inhibitory factor

Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.

Gene Name: leukemia inhibitory factor
Synonyms: LIF, DIA, Emfilermin, HILDA, Melanoma-derived LPL inhibitor, MLPLI, Leukemia inhibitory factor, CDF, D factor, Human interleukin in DA cells
Target Sequences: NM_002309 NP_002300.1 P15018

Publications (1)

1
Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Man-Tzu Wang, Nicole Fer, Jacqueline Galeas, Eric A Collisson, Sung Eun Kim, Jeremy Sharib, Frank McCormick. Nature communications. 2019 July;10:3055. [Full Text Article] [PubMed:31296870] [PMC:PMC6624260] Related Antibodies: LS-B7078.

☰ Filters
Products
Proteins (40)
Over-Expression Cell Culture Supernatant (2)
Over-Expression Lysate (4)
Recombinant (34)
LIF (40)
Animal-free (1)
No (40)
6His, N-terminus (5)
Fc, C-terminus (1)
GST (1)
His (2)
His, N-Terminal (3)
His,C-terminus (2)
His-T7 (2)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Human (23)
Mouse (13)
Rat (1)
293T Cells (1)
CHO Cells (1)
E. coli (24)
HEK 293 Cells (12)
Wheat Germ Extract (1)
Yeast (1)
Purified (9)
Low endotoxin level (20)
Biologically active (13)
Animal-free (1)
LIF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
19.7 kDa
50 µg/$516; 10 µg/$313; 1 mg/$3,095; 500 µg/$2,064
Select
HEK 293 Cells
6His, N-terminus
22 kDa
100 µg/$298
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
19.7 kDa
5 µg/$268; 25 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
19.7 kDa
5 µg/$281; 25 µg/$369
LIF Protein
Select
E. coli
None
Biologically active
19.7 kDa
5 µg/$282; 100 µg/$893; 500 µg/$1,668
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.9kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
LIF Protein - 12.5% SDS-PAGE of human LIF stained with Coomassie Blue
Select
Wheat Germ Extract
GST
48.4 kDa
2 µg/$439
LIF Protein
Select
HEK 293 Cells
His, N-Terminal
~20 kDa (30-45 kDa reducing conditions)
10 µg/$289; 200 µg/$646; 50 µg/$360
LIF Protein
Select
HEK 293 Cells
His, N-Terminal
~22 kDa (25-45 kDa reducing conditions)
10 µg/$289; 100 µg/$432; 50 µg/$360
LIF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.01 kDa
100 µg/$494
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.7kD
10 µg/$288; 50 µg/$442; 500 µg/$1,627; 1 mg/$2,353
LIF Protein - Purified recombinant protein LIF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
19.7 kDa
20 µg/$1,107
LIF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
22.01 kDa
20 µg/$150
Select
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~35 kDa (SDS-PAGE)
10 µg/$358; 50 µg/$690
LIF Protein - Recombinant Bovine leukemia inhibitory factor detected using Chicken anti Bovine leukemia inhibitory factor as the capture reagent and Chicken anti Bovine leukemia inhibitory factor:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
19.8 kDa
5 µg/$390
Select
HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.7 kDa
100 µg/$790; 20 µg/$407
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.7 kDa
20 µg/$360; 100 µg/$728
Select
E. coli
None
Biologically active
Less than 0.1 EU/µg protein (determined by LAL method).
This 180 amino acid protein has a predicted molecular mass of approximately 20 kD. The protein migrates at approximately 20 kD in DTT-reducing conditions and approximately 18 kD in non-reducing condition by SDS-PAGE. The predicted N-terminal amino acid is
10 µg/$302; 25 µg/$355; 100 µg/$820; 500 µg/$1,663
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.9 kDa
20 µg/$360; 100 µg/$728
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.2 kDa
100 µg/$928
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.7 kDa
100 µg/$928
LIF Protein - The ED(50) was determined by the dose-dependent differentiation of M1 myeloid leukemic cells was found to be in the range of 0.01 ng/mL.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~20 kDa
10 µg/$291; 100 µg/$597; 1 mg/$1,587
LIF Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~20 kDa
10 µg/$291; 100 µg/$559; 1 mg/$1,891
Select
CHO Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$1,891
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~20 kDa
10 µg/$291; 100 µg/$908; 1 mg/$2,665
Viewing 1-25 of 40 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).