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LCN2 / Lipocalin 2 / NGAL
lipocalin 2
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
| Gene Name: | lipocalin 2 |
| Synonyms: | LCN2, 24p3, HNL, Lipocalin 2, Lipocalin-2, MSFI, Siderocalin LCN2, NGAL, p25, Lipocalin 2 (oncogene 24p3), Oncogene 24p3 |
| Target Sequences: | NM_005564 NP_005555.2 P80188 |
Publications (5)
1
Clinicopathological significance of lipocalin 2 nuclear expression in invasive breast cancer. Sasagu Kurozumi, Sami Alsaeed, Nnamdi Orah, Islam M Miligy, Chitra Joseph, Abrar Aljohani, Michael S Toss, Takaaki Fujii, Ken Shirabe, Andrew R Green, Mohammed A Aleskandarany, Emad A Rakha. Breast cancer research and treatment. 2020 February;179:557-564. [Full Text Article]
[PubMed:31707510]
2
Lipocalin-2 is an anorexigenic signal in primates. Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni. eLife. 2020 November;9: [Full Text Article]
[PubMed:33231171]
[PMC:PMC7685704]
3
Implication of human nonmetastatic clone 23 Type 1 and its downstream gene lipocalin 2 in metastasis and patient's survival of cancer of uterine cervix. Wang PH, Ko JL, Yang SF, Lin LY. International journal of cancer. Journal international du cancer. 2011 Nov;129:2380-9. [Full Text Article]
[PubMed:21442621]
Related Antibodies: LS-B2496.
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LCN2 / Lipocalin 2 / NGAL Goat anti-Human Polyclonal (aa60-72) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Mouse Polyclonal (aa21-200) Antibody
Mouse, Rat
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Mouse Polyclonal (aa21-200) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
LCN2 / Lipocalin 2 / NGAL Goat anti-Rat Polyclonal (aa21-198) Antibody
Mouse, Rat
ELISA, IP, WB
Unconjugated
100 µg/$962
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
LCN2 / Lipocalin 2 / NGAL Mouse anti-Human Monoclonal (GF1) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$1,146
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$559
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$573
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich CLIA
96-Well Strip Plate
Human
27.43 - 20000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$851
Sandwich
96-Well Strip Plate
Monkey
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
LCN2 / Lipocalin 2 / NGAL Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Microplate
Human
4.1 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Microplate
Rat
32.77 - 3200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Rat Polyclonal (aa21-198) Antibody
Mouse, Rat
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
LCN2 / Lipocalin 2 / NGAL Goat anti-Mouse Polyclonal (aa127-138) Antibody
Mouse
Peptide-ELISA, WB
Unconjugated
100 µg/$503
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Pig Polyclonal (aa23-199) Antibody
Pig
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$585
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$582
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
His
21.7 kDa
10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$412
LCN2 / Lipocalin 2 / NGAL Mouse anti-Human Monoclonal (697) Antibody
Human
IF
Unconjugated
100 µg/$652
LCN2 / Lipocalin 2 / NGAL Mouse anti-Rat Monoclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µl/$1,167
LCN2 / Lipocalin 2 / NGAL Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$749
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