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KNG1 / Kininogen / Bradykinin

kininogen 1

1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Gene Name: kininogen 1
Synonyms: KNG1, Bradykinin, Flaujeac factor deficiency, Fitzgerald factor, Kininogen 1, Kininogen-1, Kininogen, BDK, HMWK, KNG
Target Sequences: NM_000893 NP_000884.1 P01042

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Antibodies (127)
ELISA Kits (40)
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KNG1 / Kininogen / Bradykinin (183)
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KNG1 / Kininogen / Bradykinin Antibody - Western blots to detect human HMWK light chain.
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KNG1 / Kininogen / Bradykinin Mouse anti-Human Monoclonal (2B5) Antibody
Human
ELISA, WB
Unconjugated
200 µg/$672
KNG1 / Kininogen / Bradykinin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (aa1-416) Antibody
Human
ICC, IHC-P, WB
Unconjugated
50 µl/$440
KNG1 / Kininogen / Bradykinin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.25 - 16 ng/ml
Colorimetric - 450nm (TMB)
Plasma
1 Plate/$715
KNG1 / Kininogen / Bradykinin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
1.23 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
KNG1 / Kininogen / Bradykinin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
1.23 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
KNG1 / Kininogen / Bradykinin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
KNG1 / Kininogen / Bradykinin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
KNG1 / Kininogen / Bradykinin Antibody - Kininogen 1 antibody IHC-paraffin. IHC(P): Mouse Kidney Tissue.
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KNG1 / Kininogen / Bradykinin Rabbit anti-Mouse Polyclonal (aa227-259) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
KNG1 / Kininogen / Bradykinin Antibody - Western blots to detect human HMWK light chain.
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KNG1 / Kininogen / Bradykinin Mouse anti-Human Monoclonal (C11C1) Antibody
Human
ELISA, Neut, WB
Unconjugated
200 µg/$672
KNG1 / Kininogen / Bradykinin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
KNG1 / Kininogen / Bradykinin Goat anti-Human Polyclonal (aa58-70) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
KNG1 / Kininogen / Bradykinin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$485
KNG1 / Kininogen / Bradykinin Antibody - Western blot of Cleaved-Kininogen-1 HC (K380) antibody
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (300-380 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KNG1 / Kininogen / Bradykinin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
KNG1 / Kininogen / Bradykinin Protein - Recombinant Kininogen 1 (KNG1) by SDS-PAGE
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E. coli
His-T7, N-terminus
43.9kDa
10 µg/$265; 50 µg/$347; 200 µg/$682; 100 µg/$545; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (aa138-166) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (aa138-166) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
KNG1 / Kininogen / Bradykinin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
KNG1 / Kininogen / Bradykinin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
KNG1 / Kininogen / Bradykinin Antibody - Anti-KNG1 / Kininogen / Bradykinin antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (aa138-166) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
KNG1 / Kininogen / Bradykinin Antibody - Anti-KNG1 / Kininogen / Bradykinin antibody IHC staining of human tonsil, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
KNG1 / Kininogen / Bradykinin Antibody - Immunoprecipitation of KNG1 transfected lysate using anti-KNG1 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with KNG1 rabbit polyclonal antibody.
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KNG1 / Kininogen / Bradykinin Mouse anti-Human Monoclonal (4A1) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
KNG1 / Kininogen / Bradykinin Antibody - KNG1 antibody (0.03 ug/ml) staining of Albumin-depleted Plasma lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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KNG1 / Kininogen / Bradykinin Goat anti-Human Polyclonal (aa268-279) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
KNG1 / Kininogen / Bradykinin Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA
Unconjugated
400 µg/$878
Select
KNG1 / Kininogen / Bradykinin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$749
Viewing 1-25 of 183 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).