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| Catalog Number | Size | Price |
|---|---|---|
| LS-B10584-50 | 50 µg (0.5 mg/ml) | $485 |
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PathPlus™ Polyclonal Goat anti‑Human KNG1 / Kininogen / Bradykinin Antibody (aa58‑70, IHC, WB) LS‑B10584
PathPlus™ Polyclonal Goat anti‑Human KNG1 / Kininogen / Bradykinin Antibody (aa58‑70, IHC, WB) LS‑B10584
Note: This antibody replaces LS-C205033
Antibody:
KNG1 / Kininogen / Bradykinin Goat anti-Human Polyclonal (aa58-70) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
KNG1 / Kininogen / Bradykinin Goat anti-Human Polyclonal (aa58-70) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
KNG1 (High-molecular-weight kininogen, HMWK) is a circulating plasma polypeptide that plays an important role in blood coagulation by helping to optimally position prekallikrein and factor XI next to factor XII. It inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. Furthermore, KNG1 peptides functions in smooth muscle contraction, the induction of hypotension, natriuresis and diuresis, regulation of blood glucose level, and regulation of inflammation and vascular permeability. In immunohistochemistry of normal tissue, it is specifically positive in plasma and has extracellular and cytoplasmic positivity in the kidney.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human KNG1 / Kininogen / Bradykinin
Synonyms
KNG1 | Bradykinin | Flaujeac factor deficiency | Fitzgerald factor | Kininogen 1 | Kininogen-1 | Kininogen | BDK | HMWK | KNG
Host
Goat
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide with sequence C-RITEATKTVGSDT, from the internal region (near N-Terminus) of the protein sequence according to NP_001095886.1NP_000884.1NP_001159923.1.
Epitope
aa58-70
Specificity
Human KNG1 / Kininogen / Bradykinin. This antibody is expected to recognize all reported isoforms (NP_001095886.1; NP_000884.1; NP_001159923.1).
Applications
- IHC - Paraffin (5 µg/ml)
- Western blot (0.3 - 1 µg/ml)
- Peptide Enzyme-Linked Immunosorbent Assay (1:128000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 80+60+30kD bands observed in Human Kidney lysates (calculated MW of 72.0kD according to NP_001095886.1). The observed MW bands are explained by glycosylation and the splitting into heavy and light chains from the precursor protein. Recommended concentration: 0.3-1 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KNG1 / Kininogen / Bradykinin
Validation
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ KNG1 / Kininogen / Bradykinin Antibody (aa58-70) for IHC, WB/Western LS-B10584 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC - Paraffin, ICC, Western blot
Species:
Human
Applications:
IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC - Paraffin, ICC, Western blot
Species:
Human
Applications:
Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/25/2024
Date Requested: 12/25/2024
