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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene Name: | kallikrein-related peptidase 15 |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | KLK15, ACO protease, ACO, HSRNASPH, Kallikrein 15, Prostinogen, Kallikrein-15 |
Target Sequences: | NM_017509 NP_059979.2 Q9H2R5 |
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