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Junctin / ASPH
aspartate beta-hydroxylase
Junctin / ASPH is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
| Gene Name: | aspartate beta-hydroxylase |
| Synonyms: | ASPH, A beta H-J-J, AAH, ASP beta-hydroxylase, BAH, Aspartate beta-hydroxylase, CASQ2BP1, Cardiac junctin, HAAH, Humbug, JCTN, Junctate, Junctin |
| Target Sequences: | NM_004318 NP_004309.2 Q12797 |
Publications (3)
1
Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D. Frontiers in physiology. 2018 October;9:1383. [Full Text Article]
[PubMed:30356673]
[PMC:PMC6189336]
Related Antibodies: LS-C196703.
2
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix. Xiaoming Zhang, Jared M McLendon, Bailey D Peck, Biyi Chen, Long-Sheng Song, Ryan L Boudreau. Molecular therapy. Nucleic acids. 2023 December;34:102081. [Full Text Article]
[PubMed:38111915]
[PMC:PMC10726423]
Related Antibodies: LS-C81640.
3
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR. Nature medicine. Feb;20:184-92. [Full Text Article]
[PubMed:24441828]
[PMC:PMC4269524]
Related Antibodies: LS-C81640.
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Junctin / ASPH Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Junctin / ASPH Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Junctin / ASPH Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Junctin / ASPH Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Junctin / ASPH Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
Junctin / ASPH Rabbit anti-Human Polyclonal (aa66-115) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
Junctin / ASPH Rabbit anti-Human Polyclonal (aa66-115) (HRP) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
Junctin / ASPH Rabbit anti-Human Polyclonal (aa66-115) (Biotin) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
Junctin / ASPH Mouse anti-Human Monoclonal (3G5) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Junctin / ASPH Rabbit anti-Human Polyclonal (aa107-156) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Junctin / ASPH Rabbit anti-Human Polyclonal (aa107-156) (HRP) Antibody
Mouse, Human, Monkey, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
Junctin / ASPH Rabbit anti-Human Polyclonal (aa107-156) (Biotin) Antibody
Mouse, Human, Monkey, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
Junctin / ASPH Rabbit anti-Human Polyclonal (aa107-156) (FITC) Antibody
Mouse, Human, Monkey, Orangutan, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Junctin / ASPH Rabbit anti-Human Polyclonal (aa312-361) Antibody
Human
WB
Unconjugated
100 µl/$397
Junctin / ASPH Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Junctin / ASPH Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Junctin / ASPH Rabbit anti-Human Polyclonal (aa726-758) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Junctin / ASPH Rabbit anti-Human Polyclonal (aa294-323) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
Junctin / ASPH Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
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product results
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