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IRAK1 / IRAK

interleukin-1 receptor-associated kinase 1

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

Gene Name: interleukin-1 receptor-associated kinase 1
Family/Subfamily: Protein Kinase , IRAK(Pelle)
Synonyms: IRAK1, IRAK-1, Pelle, Il1rak, IRAK, Pelle homolog
Target Sequences: NM_001569 NP_001560.2 P51617

☰ Filters
Antibodies (78)
Proteins (12)
ELISA Kits (7)
Cell-Based Phosphorylation (2)
Custom (1)
Over-Expression Lysate (7)
Primary (78)
Recombinant (5)
Sandwich (4)
IRAK1 / IRAK (97)
Human (76)
Mouse (33)
Rat (19)
Monkey (1)
IHC (19)
IHC-Fr (1)
IHC-P (9)
WB (70)
Flo (7)
ELISA (30)
ICC (5)
IF (11)
IP (13)
Peptide-ELISA (7)
RNAi (1)
rabbit (68)
mouse (9)
goat (1)
Product Group
IHCPlus (4)
Ig (1)
IgG (53)
IgG1 (1)
IgG1,k (1)
IgG2a (4)
IgG2a,k (2)
monoclonal mc (8)
polyclonal pc (70)
3A9 (1)
3F7 (1)
8F1A7 (1)
96-Well Microplate (2)
96-Well Strip Plate (5)
APC (1)
APC Conjugated (4)
Azide-free (2)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Unconjugated (52)
aa212-440 (8)
aa405-433 (7)
aa530-693 (5)
pThr209 (4)
pSer376 (3)
C-Terminus (2)
pThr100 (2)
pThr387 (2)
150-230 aa (1)
320-400 aa (1)
330-410 aa (1)
40-120 aa (1)
Ab-376 (1)
Ile205 (1)
Thr381 (1)
aa175-224 (1)
aa18-37 (1)
aa342-391 (1)
aa353-402 (1)
aa575-625 (1)
aa662-712 (1)
aa683-712 (1)
aa700-712 (1)
p209 (1)
p387 (1)
pT387 (1)
No (96)
Yes (1)
Adherent Cell Cultures (2)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (3)
Serum (3)
Tissue Homogenates (3)
GST (1)
GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
His (1)
Myc-DDK (Flag) (8)
Human (9)
293T Cells (4)
E. coli (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
IRAK1 / IRAK Antibody - Anti-IRAK1 / IRAK antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IRAK1 / IRAK Mouse anti-Human Monoclonal (3F7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Select
IRAK1 / IRAK Mouse anti-Human Monoclonal (aa530-693) (Biotin) Antibody
Human
ELISA, IF, WB
Biotin Conjugated
100 µl/$904
IRAK1 / IRAK Antibody - Mouse Irak1 Antibody western blot of mouse Neuro-2a cell line lysates (35 ug/lane). The Irak1 antibody detected the Irak1 protein (arrow).
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IRAK1 / IRAK Rabbit anti-Mouse Polyclonal (aa405-433) Antibody
Mouse
Flo, WB
Unconjugated
400 µl/$393
IRAK1 / IRAK Antibody - Western blot analysis of IRAK1 (pT209) expression in MCF7 IL1b-treated (A); K562 (B); MCF7 (C); Raw264.7 IL1b-treated (D) whole cell lysates.
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (pThr209) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$315
IRAK1 / IRAK Antibody - Anti-IRAK1 / IRAK antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IRAK1 / IRAK Mouse anti-Human Monoclonal (3A9) Antibody
Human
ELISA, IF, IHC, IHC-P, IP, RNAi, WB
Unconjugated
50 µg/$440
IRAK1 / IRAK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
IRAK1 / IRAK ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
IRAK1 / IRAK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
IRAK1 / IRAK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
IRAK1 / IRAK Antibody - Immunocytochemistry of IRAK in HeLa cells with IRAK antibody at 10 µg/ml.
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IRAK1 / IRAK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IP, WB
Unconjugated
0.1 mg/$448
IRAK1 / IRAK Antibody - Phospho-IRAK1(S376) Antibody staining IRAK1 in human kidney tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (pSer376) Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
200 µl/$393
IRAK1 / IRAK Antibody - WB of IRAK1 / IRAK antibody. Lane 1: Rat Liver Tissue Lysate. Lane 2: Human Placenta Tissue Lysate. Lane 3: MCF-7 Cell Lysate. Lane 4: PANC Cell Lysate.
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa18-37) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
IRAK1 / IRAK Antibody - Anti-IRAK1 / IRAK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa175-224) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
IRAK1 / IRAK Antibody - Immunohistochemistry of IRAK in rat liver tissue with IRAK antibody at 5 ug/ml.
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IRAK1 / IRAK Mouse anti-Human Monoclonal (8F1A7) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$502
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (40-120 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IRAK1 / IRAK Antibody - Western blot of IRAK-1 antibody
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (330-410 aa) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
IRAK1 / IRAK Rabbit anti-Mouse Polyclonal (aa405-433) (Biotin) Antibody
Mouse
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (pT387) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (150-230 aa) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IRAK1 / IRAK Antibody - Western blot analysis of lysates from HeLa cells, using IRAK1 Antibody. The lane on the right is blocked with the synthesized peptide.
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IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa353-402) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IRAK1 / IRAK Antibody - Western blot analysis of lysates from HeLa cells, using IRAK1 (Phospho-Thr209) Antibody. The lane on the right is blocked with the phospho peptide.
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (pThr209) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
IP, WB
Biotin Conjugated
100 µl/$1,006
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
IRAK1 / IRAK Antibody - Western blot of recombinant IRAK1 / IRAK.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa212-440) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
IRAK1 / IRAK Antibody - Anti-IRAK1 / IRAK antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa683-712) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
Viewing 1-25 of 97 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).