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IL1R1

interleukin 1 receptor, type I

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Name: interleukin 1 receptor, type I
Family/Subfamily: Interleukin
Synonyms: IL1R1, Antigen CD121a, D2S1473, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1RA, IL1RT1, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, CD121A, CD121a antigen, Interleukin 1 receptor, type I, Interleukin-1 receptor type I, Interleukin-1 type i receptor, p80
Target Sequences: NM_000877 NP_000868.1 P14778

Publications (2)

1
IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Suzuki M, Hashizume M, Yoshida H, Shiina M, Mihara M. Cytokine. 2010 51:178-83. (WB) [PubMed:20403707]
2
The role of interleukin-1ß in human trophoblast motility. Prutsch N, Fock V, Haslinger P, Haider S, Fiala C, Pollheimer J, Knöfler M. Placenta. 2012 33:696-703. (ELISA; Human) [Full Text Article] [PubMed:22710193] Related Antibodies: LS-B2859.

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Products
Antibodies (149)
Primary (149)
IL1R1 (149)
Human (78)
Mouse (49)
Rat (39)
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WB (109)
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ELISA (52)
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ID (2)
IF (1)
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rabbit (119)
mouse (10)
goat (1)
hamster (4)
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Product Group
Coronavirus Antibodies Proteins cDNAs (149)
Cytokine Release Syndrome Antibodies (149)
IHCPlus (3)
IgG (40)
IgG1 (14)
IgG2a (3)
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monoclonal mc (30)
polyclonal pc (119)
08 (1)
10 (1)
35730 (49/20) (1)
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D14e3 (2)
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D1f3 (2)
IL1-31-104.1.1 (1)
IL1-31-113.1.1 (1)
IL1-31-22.2.1 (1)
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Unconjugated (65)
aa120-208 (10)
aa386-553 (10)
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aa20-338 (8)
aa21-109 (8)
aa226-318 (8)
aa226-352 (8)
aa422-450 (7)
aa474-503 (7)
pTyr496 (6)
Extracellular Domain (4)
aa488-537 (4)
aa18-320 (2)
31-80 aa, N-terminal (1)
pY496 (1)
No (148)
Yes (1)
IL1R1 Antibody - Anti-IL1R1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IL1R1 Mouse anti-Human Monoclonal (Extracellular Domain) (IL1-31-22.2.1) Antibody
Human
ELISA, IHC, IHC-P, RIA
Unconjugated
50 µg/$460
IL1R1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL1R1 Rabbit anti-Human Polyclonal (aa488-537) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL1R1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL1R1 Rabbit anti-Human Polyclonal (aa488-537) (Biotin) Antibody
Mouse, Dog, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
IL1R1 Antibody - Anti-IL1R1 antibody IHC staining of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IL1R1 Rabbit anti-Human Polyclonal (aa474-503) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
IL1R1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
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IL1R1 Rabbit anti-Human Polyclonal (aa18-320) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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IL1R1 Goat anti-Human Polyclonal (Extracellular Domain) (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$896
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IL1R1 Mouse anti-Human Monoclonal (Extracellular Domain) (IL1-31-104.1.1) Antibody
Human
ELISA, IHC, RIA
Unconjugated
200 µg/$484
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IL1R1 Mouse anti-Human Monoclonal (4D2D12) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
IL1R1 Antibody - Immunofluorescent analysis of A549 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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IL1R1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
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IL1R1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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IL1R1 Rat anti-Mouse Monoclonal Antibody
Mouse
Func, ID, IP, Neut, WB
Unconjugated
100 µg/$752
IL1R1 Antibody - Western blot of recombinant IL1RA / IL1R1.
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IL1R1 Rabbit anti-Mouse Polyclonal (aa20-338) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
IL1R1 Antibody - Western blot of recombinant IL1RA / IL1R1.
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IL1R1 Rabbit anti-Mouse Polyclonal (aa20-338) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$483; 200 µl/$599; 500 µl/$1,089; 1 ml/$1,297; 2 ml/$1,815; 5 ml/$3,403
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IL1R1 Rabbit anti-Mouse Monoclonal (PE) Antibody
Mouse
Flo
PE Conjugated
25 Tests/$233; 100 Tests/$263
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IL1R1 Rat anti-Mouse Monoclonal Antibody
Mouse
Func, ID, Neut, WB
Unconjugated
100 µg/$826
IL1R1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
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IL1R1 Rabbit anti-Human Polyclonal (aa18-320) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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IL1R1 Rabbit anti-Human Polyclonal (pY496) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IL1R1 Antibody - Western blot of IL-1RI antibody
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IL1R1 Rabbit anti-Human Polyclonal (31-80 aa, N-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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IL1R1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
Flo
Unconjugated
100 µl/$412
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IL1R1 Rat anti-Mouse Monoclonal (CF) Antibody
Mouse
Flo
CF Conjugated
100 Tests/$678
IL1R1 Antibody - Western blot of recombinant IL1RA / IL1R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL1R1 Rabbit anti-Rat Polyclonal (aa386-553) (FITC) Antibody
Rat
WB
FITC Conjugated
100 µl/$325
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IL1R1 Mouse anti-Human Monoclonal (Extracellular Domain) (IL1-31-113.1.1) Antibody
Human
ELISA, IHC, RIA
Unconjugated
200 µg/$484
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IL1R1 Rabbit anti-Human Polyclonal (aa474-503) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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IL1R1 Rabbit anti-Human Polyclonal (aa474-503) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
IL1R1 Antibody - Western Blot; Sample: Recombinant IL1R1, Human.
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IL1R1 Rabbit anti-Human Polyclonal (aa21-109) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).