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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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IL-33
interleukin 33
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
Gene Name:
interleukin 33
Family/Subfamily:
Interleukin
Synonyms:
IL33, C9orf26, DVS27, DVS27-related protein, IL-1F11, IL-33, Interleukin-33, NFEHEV, NF-HEV, Interleukin-1 family member 11, NFHEV, IL1F11, Interleukin 33, RP11-575C20.2
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article]
[PubMed:30185520]
Related Antibodies: LS-C104697.
2
Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway. George S Hussey, Jenna L Dziki, Yoojin C Lee, Joseph G Bartolacci, Marissa Behun, Heth R Turnquist, Stephen F Badylak. Journal of immunology and regenerative medicine. 2019 March;3:26-35. [Full Text Article]
[PubMed:31656879]
[PMC:PMC6814021]
3
A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes. Eva Haas , Rana D Incebacak , Thomas Hentrich , Chrisovalantou Huridou , Thorsten Schmidt , Nicolas Casadei , Yacine Maringer , Carola Bahl , Frank Zimmermann, James D Mills, Eleonora Aronica, Olaf Riess , Julia M Schulze-Hentrich , Jeannette Hübener-Schmid. Molecular neurobiology. 2022 Jan;;59:495-522. [Full Text Article]
[PubMed:34716557]
[PMC:PMC8786755]
Related Antibodies: LS-C294906.
4
Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model. Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang, Jui-Hung Yen. Stem cell research & therapy. 2022 July;13:357. [Full Text Article]
[PubMed:35883204]
[PMC:PMC9327360]
5
Elevations in Th2-initiating cytokines (IL-33, IL-25, TSLP) in lesional skin from Chronic Spontaneous ("Idiopathic") Urticaria. Clark P, Maurer M, Ying S. The British journal of dermatology. Dec; [Full Text Article]
[PubMed:25523947]
Related Antibodies: LS-C104697.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).