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IL-33
interleukin 33
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
| Gene Name: | interleukin 33 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL33, C9orf26, DVS27, DVS27-related protein, IL-1F11, IL-33, Interleukin-33, NFEHEV, NF-HEV, Interleukin-1 family member 11, NFHEV, IL1F11, Interleukin 33, RP11-575C20.2 |
| Target Sequences: | NM_033439 NP_254274.1 O95760 |
Publications (5)
1
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article]
[PubMed:30185520]
Related Antibodies: LS-C104697.
2
Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway. George S Hussey, Jenna L Dziki, Yoojin C Lee, Joseph G Bartolacci, Marissa Behun, Heth R Turnquist, Stephen F Badylak. Journal of immunology and regenerative medicine. 2019 March;3:26-35. [Full Text Article]
[PubMed:31656879]
[PMC:PMC6814021]
3
A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes. Eva Haas , Rana D Incebacak , Thomas Hentrich , Chrisovalantou Huridou , Thorsten Schmidt , Nicolas Casadei , Yacine Maringer , Carola Bahl , Frank Zimmermann, James D Mills, Eleonora Aronica, Olaf Riess , Julia M Schulze-Hentrich , Jeannette Hübener-Schmid. Molecular neurobiology. 2022 Jan;;59:495-522. [Full Text Article]
[PubMed:34716557]
[PMC:PMC8786755]
Related Antibodies: LS-C294906.
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IL-33 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
IL-33 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL-33 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
IL-33 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$962
IL-33 Mouse anti-Human Monoclonal (aa112-270) (6H617) Antibody
Human
Flo, WB
Unconjugated
100 µg/$386
IL-33 Mouse anti-Human Monoclonal (IL33026B) Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
50 µg/$354; 100 µg/$407
IL-33 Mouse anti-Human Monoclonal (aa112-270) (4E9) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
IL-33 Rabbit anti-Mouse Polyclonal (aa109-266) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL-33 Rabbit anti-Mouse Polyclonal (aa109-266) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
IL-33 Mouse anti-Human Monoclonal (IL33305B) Antibody
Human
ELISA, Func, IHC, IHC-P, Inhb, IP, WB
Unconjugated
50 µg/$365; 100 µg/$449
IL-33 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
Sandwich
96-Well Strip Plate
Dog
23.44 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
IL-33 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$323
IL-33 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
20 µl/$256; 100 µl/$412
Sandwich
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$414
Sandwich CLIA
96-Well Strip Plate
Mouse
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$871
IL-33 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
100 µg/$552
IL-33 Mouse anti-Dog Monoclonal (IgG1) Antibody
Dog
ELISA
Unconjugated
100 µl/$412
IL-33 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Human
WB
Unconjugated
100 µg/$386
IL-33 Rabbit anti-Human Monoclonal (Preservative Free) (002) Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated, Preservative Free
50 µl/$322; 100 µl/$382
Sandwich
12 x 8-Well Microstrips
Mouse
16 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
E. coli
His, N-Terminal
34.6 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
IL-33 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
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