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IL-33

interleukin 33

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).

Gene Name: interleukin 33
Family/Subfamily: Interleukin
Synonyms: IL33, C9orf26, DVS27, DVS27-related protein, IL-1F11, IL-33, Interleukin-33, NFEHEV, NF-HEV, Interleukin-1 family member 11, NFHEV, IL1F11, Interleukin 33, RP11-575C20.2
Target Sequences: NM_033439 NP_254274.1 O95760

Publications (5)

1
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article] [PubMed:30185520] Related Antibodies: LS-C104697.
2
Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway. George S Hussey, Jenna L Dziki, Yoojin C Lee, Joseph G Bartolacci, Marissa Behun, Heth R Turnquist, Stephen F Badylak. Journal of immunology and regenerative medicine. 2019 March;3:26-35. [Full Text Article] [PubMed:31656879] [PMC:PMC6814021]
3
A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes. Eva Haas , Rana D Incebacak , Thomas Hentrich , Chrisovalantou Huridou , Thorsten Schmidt , Nicolas Casadei , Yacine Maringer , Carola Bahl , Frank Zimmermann, James D Mills, Eleonora Aronica, Olaf Riess , Julia M Schulze-Hentrich , Jeannette Hübener-Schmid. Molecular neurobiology. 2022 Jan;;59:495-522. [Full Text Article] [PubMed:34716557] [PMC:PMC8786755] Related Antibodies: LS-C294906.
4
Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model. Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang, Jui-Hung Yen. Stem cell research & therapy. 2022 July;13:357. [Full Text Article] [PubMed:35883204] [PMC:PMC9327360]
5
Elevations in Th2-initiating cytokines (IL-33, IL-25, TSLP) in lesional skin from Chronic Spontaneous ("Idiopathic") Urticaria. Clark P, Maurer M, Ying S. The British journal of dermatology. Dec; [Full Text Article] [PubMed:25523947] Related Antibodies: LS-C104697.
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☰ Filters
Antibodies (156)
Proteins (38)
ELISA Kits (34)
Custom (2)
Development Kit (2)
Over-Expression Lysate (2)
Primary (156)
Recombinant (36)
Sandwich (24)
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IL-33 (228)
Human (129)
Mouse (30)
Rat (62)
Chimpanzee (3)
Dog (4)
Monkey (3)
IHC (21)
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WB (128)
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ELISA (59)
Func (1)
ICC (3)
IF (11)
Inhb (1)
IP (2)
Peptide-ELISA (1)
rabbit (95)
mouse (57)
goat (3)
rat (1)
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IgG (51)
IgG1 (2)
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monoclonal mc (59)
polyclonal pc (97)
002 (1)
1D11C3F3 (1)
25 (1)
27 (1)
34 (1)
48 (1)
4E9 (1)
6H617 (1)
IgG1 (1)
IL33026B (1)
IL33068A (1)
IL33305B (1)
SB127c (2)
SB127j (2)
1000 Wells (1)
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96-Well Microplate (5)
96-Well Strip Plate (24)
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aa112-270 (18)
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121-170 aa, Internal (1)
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6His, N-terminus (2)
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Human (21)
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IL-33 Antibody - Anti-IL-33 antibody IHC of human uterus, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IL-33 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
IL-33 Antibody - Western Blot (non-reducing) of IL-33 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-33 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL-33 Antibody - Anti-IL-33 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-33 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
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IL-33 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$962
IL-33 Antibody - Immunoprecipitation of recombinant IL-33 proteins using anti-IL-33 (human), mAb (IL33026B) . Recombinant IL-33 proteins at different concentrations were precipitated by anti-IL-33 mAb (IL33026B). The precipitated proteins were separated by SDS-PAGE, electroblotted, and visualized by western blot. 1. Control 100ng. 2. IP : 1 ug. 3. IP : 500ng. 4. IP : 250ng. 5. IP : 125ng
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IL-33 Mouse anti-Human Monoclonal (IL33026B) Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
50 µg/$354; 100 µg/$407
IL-33 Antibody - Western blot of IL-33 using IL-33 monoclonal antibody in A) HUVEC cell lysate at 10 ug/ml and B) partial recombinant IL-33 (amino acids 112-270) at 1 ug/ml. Goat anti-mouse Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
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IL-33 Mouse anti-Human Monoclonal (aa112-270) (6H617) Antibody
Human
Flo, WB
Unconjugated
100 µg/$386
IL-33 Antibody - The Cell lysates of Jurkat (35 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human IL-33 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
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IL-33 Mouse anti-Human Monoclonal (aa112-270) (4E9) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
IL-33 Antibody - Western blot of recombinant IL33.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-33 Rabbit anti-Mouse Polyclonal (aa109-266) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL-33 Antibody - Western blot of recombinant IL33.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-33 Rabbit anti-Mouse Polyclonal (aa109-266) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
IL-33 Antibody - Immunohistochemical staining of human tissue using anti-IL-33 (human), mAb (IL33305B) at 1:100 dilution. A. Immunoperoxidase staining (cytoplasmic) of formalin-fixed, paraffin-embedded human heart (100x, brown color). B. Isotype control with IgG2a (negative control).
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IL-33 Mouse anti-Human Monoclonal (IL33305B) Antibody
Human
ELISA, Func, IHC, IHC-P, Inhb, IP, WB
Unconjugated
50 µg/$365; 100 µg/$449
IL-33 Antibody - Immunofluorescence of IL-33 in Human Lymph Node cells with IL-33 antibody at 20 ug/ml.
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IL-33 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
IL-33 ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
23.44 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
IL-33 Antibody - Immunohistochemical staining of human lymph node tissue using A) anti-IL-33 (human), pAb and B) anti-rabbit IgG (negative control) .  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL-33 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$323
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IL-33 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
20 µl/$256; 100 µl/$412
IL-33 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$414
IL-33 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$871
IL-33 Antibody - Western blot using anti-Human IL-33 antibody shows detection of a band ~18 kDa in size corresponding to recom-binant human IL-33 (lane 1). The identity of the higher molecular weight band is unknown. Molecular weight markers are also shown (M). After transfer, the membrane was blocked overnight with 3% BSA in TBS followed by reaction with primary antibody at a 1:1,000 dilution. Detection occurred using peroxidase conjugated anti-Rabbit IgG secondary antibody diluted 1:40,000 in blocking buffer for 30 min at RT followed by reaction with FemtoMax™ chemiluminescent substrate. Image was captured using VersaDoc™ MP 4000 imaging system (Bio-Rad).
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IL-33 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
100 µg/$552
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IL-33 Mouse anti-Dog Monoclonal (IgG1) Antibody
Dog
ELISA
Unconjugated
100 µl/$412
IL-33 Antibody - Western blot of human IL-33inHUVEC cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at1 ug/ml.
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IL-33 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Human
WB
Unconjugated
100 µg/$386
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IL-33 Rabbit anti-Human Monoclonal (Preservative Free) (002) Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated, Preservative Free
50 µl/$322; 100 µl/$382
IL-33 ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Mouse
16 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
IL-33 Protein - Recombinant Interleukin 33 By SDS-PAGE
Select
E. coli
His, N-Terminal
34.6 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
IL-33 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
IL-33 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
IL-33 Antibody - Western blot - Anti-IL33 Picoband Antibody
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IL-33 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
Viewing 1-25 of 228 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).