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IGFBP3

insulin-like growth factor binding protein 3

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: insulin-like growth factor binding protein 3
Synonyms: IGFBP3, Binding protein 29, Binding protein 53, BP-53, IGF-binding protein 3, IGFBP-3, IBP-3, IBP3
Target Sequences: NM_000598 NP_000589.2 P17936

Publications (2)

1
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J. Nature communications. 2016 7:13685. (WB; Human) [Full Text Article] [PubMed:27897169] Related Antibodies: LS-C407922.
2
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha Jr, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zu. Nature communications. 2022 February;13:684. [Full Text Article] [PubMed:35115561] [PMC:PMC8813914] Related Antibodies: LS-C340284.

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Proteins (20)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (14)
IGFBP3 (20)
Animal-free (1)
No (20)
6His, N-terminus (3)
GST, N-terminus (1)
His (5)
His-T7 (2)
Myc-DDK (Flag) (4)
Bovine (1)
Human (14)
Mouse (1)
Pig (1)
Rat (1)
293T Cells (2)
E. coli (12)
HEK 293 Cells (4)
Human Cells (1)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (5)
Biologically active (4)
Animal-free (1)
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E. coli
His
17.9 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
28.8 kDa
5 µg/$268; 25 µg/$349
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E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 25 µg/$370
IGFBP3 Protein
Select
E. coli
None
Biologically active
28.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
IGFBP3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
31 kDa
100 µg/$897; 1 mg/$3,729
IGFBP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
31.67 kDa
20 µg/$150
IGFBP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.21 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
28.8 kDa
1 mg/$2,653; 25 µg/$364
IGFBP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
31.67 kDa
100 µg/$494
IGFBP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.21 kDa
100 µg/$494
IGFBP3 Protein
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~28 kDa
25 µg/$466; 100 µg/$1,416; 1 mg/$4,915
IGFBP3 Protein - Recombinant Insulin Like Growth Factor Binding Protein 3 By SDS-PAGE
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E. coli
His-T7
19.1 kDa
10 µg/$285; 50 µg/$462; 100 µg/$740; 200 µg/$925; 1 mg/$2,047; 500 µg/$1,581; 5 mg/$3,235; 2 mg/$2,236
IGFBP3 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
32 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
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HEK 293 Cells
6His, N-terminus
40-50 kDa
100 µg/$298
Select
HEK 293 Cells
6His, N-terminus
40-50 kDa
200 µl/$283
IGFBP3 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
IGFBP3 Protein - Recombinant Insulin Like Growth Factor Binding Protein 3 By SDS-PAGE
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E. coli
His-T7
18.7 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
IGFBP3 Protein - Recombinant Insulin Like Growth Factor Binding Protein 3 By SDS-PAGE
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E. coli
His
22 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
IGFBP3 Protein - Recombinant Insulin Like Growth Factor Binding Protein 3 By SDS-PAGE
Select
E. coli
His
17.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).