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IGFBP3

insulin-like growth factor binding protein 3

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: insulin-like growth factor binding protein 3
Synonyms: IGFBP3, Binding protein 29, Binding protein 53, BP-53, IGF-binding protein 3, IGFBP-3, IBP-3, IBP3
Target Sequences: NM_000598 NP_000589.2 P17936

Publications (2)

1
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Lui JC, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, Jee YH, Landman E, Nilsson O, Barnes KM, Baron J. Nature communications. 2016 7:13685. (WB; Human) [Full Text Article] [PubMed:27897169] Related Antibodies: LS-C407922.
2
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F Markmann, Emanuela Orsi, Jan Škrha Jr, Maria Gabriella Camboni, Reza Abdi, A M James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zu. Nature communications. 2022 February;13:684. [Full Text Article] [PubMed:35115561] [PMC:PMC8813914] Related Antibodies: LS-C340284.

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Products
ELISA Kits (40)
Cell-Based (1)
Competitive EIA (2)
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Sandwich (29)
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IGFBP3 (40)
Human (13)
Mouse (10)
Rat (7)
Bovine (1)
Chicken (2)
Dog (1)
Monkey (1)
Pig (5)
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12 x 8-Well Microstrips (4)
96-Well Microplate (10)
96-Well Strip Plate (24)
Antibody Pair and Standard (2)
No (40)
Adherent Cell Cultures (1)
Cell Culture Supernatants (10)
Cell Lysates (4)
Cell Supernatant (1)
Plasma (34)
Serum (36)
Tissue Homogenates (15)
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$441
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
54.87 - 40000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
156.2 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Human
74 - 18000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.94 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
IGFBP3 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IGFBP3 ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$964; 1000 Wells/$1,383
IGFBP3 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
500 Wells/$1,352; 1000 Wells/$2,029
IGFBP3 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$713
IGFBP3 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$699
IGFBP3 ELISA Kit
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Sandwich
96-Well Microplate
Human
156.2 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$573
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$779
IGFBP3 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$779
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).