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IGF2R / CD222
insulin-like growth factor 2 receptor
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
| Gene Name: | insulin-like growth factor 2 receptor |
| Synonyms: | IGF2R, CD222 antigen, CIMPR, CI Man-6-P receptor, CI-MPR, IGF-II receptor, MPR 300, MPR1, MPRI, M6P-R, M6P/IGF2R, CD222, M6P/IGF2 receptor |
| Target Sequences: | NM_000876 NP_000867.2 P11717 |
Publications (1)
1
Secretion of parathyroid hormone may be coupled to insulin secretion in humans. Marie Reeberg Sass, Nicolai Jacob Wewer Albrechtsen, Jens Pedersen, Kristine Juul Hare, Nis Borbye-Lorenzen, Katalin Kiss, Tina Vilsbøll, Filip Krag Knop, Steen Seier Poulsen, Niklas Rye Jørgensen, Jens Juul Holst, Cathrine Ørskov, Bolette Hartmann. Endocrine connections. 2020 July;9:747-754. [Full Text Article]
[PubMed:32698134]
[PMC:PMC7424341]
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IGF2R / CD222 Mouse anti-Human Monoclonal (MEM-240) Antibody
Human
Flo, IP, WB
Unconjugated
0.1 mg/$316
IGF2R / CD222 Rabbit anti-Human Polyclonal (aa2441-2490) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
IGF2R / CD222 Mouse anti-Human Monoclonal (4F1G1) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IGF2R / CD222 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
IGF2R / CD222 Mouse anti-Human Monoclonal (PE) (MEM-238) Antibody
Mouse, Human, Non-Human Primate
Flo
PE Conjugated
100 Tests/$493
IGF2R / CD222 Mouse anti-Human Monoclonal (MEM-238) Antibody
Human, Non-Human Primates
Flo, IP, WB
Unconjugated
0.1 mg/$316
IGF2R / CD222 Mouse anti-Human Monoclonal (APC) (MEM-238) Antibody
Human, Non-Human Primates
Flo, IP, WB
APC Conjugated
100 Tests/$365
IGF2R / CD222 Mouse anti-Bovine Monoclonal (2G11) Antibody
Mouse, Bovine, Rat, Primate, Human
ELISA, Flo, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$386
IGF2R / CD222 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
E. coli
His, N-Terminal
28.3 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
IGF2R / CD222 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$351
IGF2R / CD222 Rabbit anti-Human Polyclonal (aa2475-2491) Antibody
Guinea pig, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IGF2R / CD222 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IGF2R / CD222 Rabbit anti-Human Polyclonal (aa2381-2430) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
E. coli
His, N-Terminal
28.4 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
IGF2R / CD222 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
IGF2R / CD222 Rabbit anti-Human Polyclonal (Ab-2409) Antibody
Mouse, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
IGF2R / CD222 Rabbit anti-Human Polyclonal (pSer2409) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IGF2R / CD222 Rabbit anti-Human Polyclonal (Phe2480) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
IGF2R / CD222 Mouse anti-Human Monoclonal (MEM-238) Antibody
Human
Flo, IF
Unconjugated
25 µg/$301; 0.2 mg/$545
IGF2R / CD222 Rabbit anti-Human Polyclonal (2350-2430 aa) Antibody
Mouse, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IGF2R / CD222 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
IGF2R / CD222 Rabbit anti-Human Polyclonal (pSer2409) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
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