Target
Human IGF2R / CD222
Synonyms
IGF2R | CD222 antigen | CIMPR | CI Man-6-P receptor | CI-MPR | IGF-II receptor | MPR 300 | MPR1 | MPRI | M6P-R | M6P/IGF2R | CD222 | M6P/IGF2 receptor
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated.
Also available conjugated with
PE.
Purification
Purified from tissue culture supernatant by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Immunogen
Recombinant Vaccinia virus encoding CD222
Specificity
The antibody MEM-238 recognizes an epitope between amino acids 698-1262 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.