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Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.
Gene Name: | iduronate 2-sulfatase |
Synonyms: | IDS, SIDS, Iduronate 2-sulfatase, MPS2 |
Target Sequences: | NM_000202 NP_000193.1 P22304 |
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