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IDO1 / IDO
indoleamine 2,3-dioxygenase 1
IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
| Gene Name: | indoleamine 2,3-dioxygenase 1 |
| Synonyms: | IDO1, IDO, Indole 2,3-dioxygenase, Indolamine 2,3 dioxygenase, IDO-1, INDO, Indoleamine 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1 |
| Target Sequences: | NM_002164 AAA36081.1 P14902 |
Publications (13)
1
Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang JZ, Matsushima K, Cao Q, Zhang Y. Journal of immunology (Baltimore, Md. : 1950). 2006 177:8226-33.
[PubMed:17114500]
Related Antibodies: LS-C153780.
2
Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. Batista CE, Juhsz C, Muzik O, Kupsky WJ, Barger G, Chugani HT, Mittal S, Sood S, Chakraborty PK, Chugani DC. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 11:460-6.
[PubMed:19434461]
[PMC:PMC2763988]
Related Antibodies: LS-C153780.
3
Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice. Hu P, Thinschmidt JS, Caballero S, Adamson S, Cole L, Chan-Ling T, Grant MB. American journal of physiology. Endocrinology and metabolism. 2015 308:E688-98. (IHC, IF; Mouse)
[Full Text Article]
[PubMed:25714673]
[PMC:PMC4398829]
Related Antibodies: LS-B1746.
☰ Filters
Products
Proteins
(23)
Type
Over-Expression Lysate
(2)
Recombinant
(21)
Target
IDO1 / IDO
(23)
Application
SDS-PAGE
(2)
Publications
No
(23)
Tag
6His, N-terminus
(6)
GST, N-terminus
(2)
His
(6)
His, N-Terminal
(2)
His,N-terminus
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(15)
Mouse
(5)
Rat
(2)
Source
293T Cells
(1)
E. coli
(16)
HEK 293 Cells
(2)
Wheat Germ Extract
(2)
Yeast
(2)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(5)
Biologically Active
Biologically active
(3)
Yeast
6His, N-terminus
47.3 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
E. coli
His, N-Terminal
46.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$1,107
E. coli
His
49.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
His
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~40kDa (SDS-PAGE)
50 µg/$512
Wheat Germ Extract
GST, N-terminus
70.07 kDa
10 µg/$479; 25 µg/$670
E. coli
His,N-terminus
SDS-PAGE
Biologically active
The recombinant human IDO1 consisting of 409 amino acids and has a calculated molecular mass of 46 kDa. It migrates as an approximately 44 kDa band in SDS-PAGE under reducing conditions.
50 µg/$403
E. coli
None
SDS-PAGE
Biologically active
The recombinant human IDO1 consists of 403 amino acids and predicts a molecular mass of 45.2 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.
50 µg/$403
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.1kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
293T Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
100 µg/$494
E. coli
His, N-Terminal
43kDa
10 µg/$331; 50 µg/$752; 200 µg/$1,365; 100 µg/$1,156; 1 mg/$2,648; 500 µg/$2,144; 5 mg/$5,251; 2 mg/$2,838
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.8 kDa
10 µg/$344; 50 µg/$584
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.1 kDa
10 µg/$344; 50 µg/$584
E. coli
His-T7
23.0 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
E. coli
His
11.2 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
10.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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