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IDO1 / IDO

indoleamine 2,3-dioxygenase 1

IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

Gene Name: indoleamine 2,3-dioxygenase 1
Synonyms: IDO1, IDO, Indole 2,3-dioxygenase, Indolamine 2,3 dioxygenase, IDO-1, INDO, Indoleamine 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1
Target Sequences: NM_002164 AAA36081.1 P14902

Publications (13)

1
Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang JZ, Matsushima K, Cao Q, Zhang Y. Journal of immunology (Baltimore, Md. : 1950). 2006 177:8226-33. [PubMed:17114500] Related Antibodies: LS-C153780.
2
Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. Batista CE, Juhsz C, Muzik O, Kupsky WJ, Barger G, Chugani HT, Mittal S, Sood S, Chakraborty PK, Chugani DC. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 11:460-6. [PubMed:19434461] [PMC:PMC2763988] Related Antibodies: LS-C153780.
3
Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice. Hu P, Thinschmidt JS, Caballero S, Adamson S, Cole L, Chan-Ling T, Grant MB. American journal of physiology. Endocrinology and metabolism. 2015 308:E688-98. (IHC, IF; Mouse) [Full Text Article] [PubMed:25714673] [PMC:PMC4398829] Related Antibodies: LS-B1746.
4
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions. Gulati N, Suárez-Fariñas M, Correa da Rosa J, Krueger JG. F1000Research. 2015 4:149. (IHC; Human) [Full Text Article] [PubMed:26236467] [PMC:PMC4505786] Related Antibodies: LS-C153780.
5
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina. Hu P, Hunt NH, Arfuso F, Shaw LC, Uddin MN, Zhu M, Devasahayam R, Adamson SJ, Benson VL, Chan-Ling T, Grant MB,. Investigative ophthalmology & visual science. 2017 58:5043-5055. (ELISA; Human) [Full Text Article] [PubMed:28980000] Related Antibodies: LS-B1746.
6
Clinical significance of tryptophan catabolism in Hodgkin lymphoma. Masaki A, Ishida T, Maeda Y, Ito A, Suzuki S, Narita T, Kinoshita S, Takino H, Yoshida T, Ri M, Kusumoto S, Komatsu H, Inagaki H, Ueda R, Choi I, Suehiro Y, Iida S. Cancer science. 2018 January;109:74-83. (Human) [Full Text Article] [PubMed:29080383] [PMC:PMC5765298] Related Antibodies: LS-C338105.
7
Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment. Schafer CC, Wang Y, Hough KP, Sawant A, Grant SC, Thannickal VJ, Zmijewski J, Ponnazhagan S, Deshane JS. Oncotarget. 2016 November;7:75407-75424. [Full Text Article] [PubMed:27705910] [PMC:PMC5340181] Related Antibodies: LS-C153780.
8
IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression. Ohmatsu H, Humme D, Gonzalez J, Gulati N, Möbs M, Sterry W, Krueger JG. Oncoimmunology. 2016 May;6:e1181237. [Full Text Article] [PubMed:28344860] [PMC:PMC5353917] Related Antibodies: LS-C153780.
9
Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. January Weiner rd, Shreemanta K Parida, Jeroen Maertzdorf, Gillian F Black, Dirk Repsilber, Anna Telaar, Robert P Mohney, Cordelia Arndt-Sullivan, Christian A Ganoza, Kellen C Faé, Gerhard Walzl, Stefan H E Kaufmann. PloS one. 2012 July;7:e40221. [Full Text Article] [PubMed:22844400] [PMC:PMC3402490] Related Antibodies: LS-B1746.
10
Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog. Miguel Tavares Pereira, Renata Nowaczyk, Rita Payan-Carreira, Sonia Miranda, Selim Aslan, Duygu Kaya, Mariusz P Kowalewski. Frontiers in veterinary science. 2021 Feb;7:625921. [Full Text Article] [PubMed:33634180] [PMC:PMC7900146] Related Antibodies: LS-C174759.
11
Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair. LaTonya J Hickson, Alfonso Eirin, Sabena M Conley, Timucin Taner, Xiaohui Bian, Ahmed Saad, Sandra M Herrmann, Ramila A Mehta, Travis J McKenzie, Todd A Kellogg, James L Kirkland, Tamar Tchkonia, Ishran M Saadiq, Hui Tang, Kyra L Jordan, Xiangyang Zhu, Mathew D Griffin, Andrew D Rule, Andre J van Wijnen, Stephen C Textor, Lilach O Lerman. Diabetes. 2021 July;70:1561-1574. [Full Text Article] [PubMed:33858824] [PMC:PMC8336004]
12
Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Liu. The European journal of neuroscience. 2020 December;52:4586-4601. [Full Text Article] [PubMed:33098156] Related Antibodies: LS-C153837.
13
Indoleamine 2,3-dioxygenase affects the aggressiveness of intraductal papillary mucinous neoplasms through Foxp3+CD4+CD25+ T cells in peripheral blood. Ikemoto T, Shimada M, Komatsu M, Yamada S, Saito Y, Mori H, Morine Y, Imura S, Bando Y, Utsunomiya T. Pancreas. 2013 Jan;42:130-4. [Full Text Article] [PubMed:22722263] Related Antibodies: LS-C123833.
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Proteins (23)
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Recombinant (21)
IDO1 / IDO (23)
SDS-PAGE (2)
No (23)
6His, N-terminus (6)
GST, N-terminus (2)
His (6)
His, N-Terminal (2)
His,N-terminus (1)
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Myc-DDK (Flag) (3)
Human (15)
Mouse (5)
Rat (2)
293T Cells (1)
E. coli (16)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (2)
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Low endotoxin level (5)
Biologically active (3)
IDO1 / IDO Protein
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Human IDO1 / IDO Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G22961
Yeast
6His, N-terminus
47.3 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
Select
Human IDO1 / IDO Protein (Recombinant His) (Full Length) - LS-G20843
E. coli
His
49.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
IDO1 / IDO Protein - Recombinant Indoleamine-2,3-Dioxygenase By SDS-PAGE
Select
Human IDO1 / IDO Protein (Recombinant His, N-Terminal) (Ala2-Gly403) - LS-G13978
E. coli
His, N-Terminal
46.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
IDO1 / IDO Protein - Purified recombinant protein IDO1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human IDO1 / IDO Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66015
HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$1,107
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Mouse IDO1 / IDO Protein (Recombinant His) (aa1-407) - LS-G3740
E. coli
His
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~40kDa (SDS-PAGE)
50 µg/$512
IDO1 / IDO Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Human IDO1 / IDO Protein (Recombinant GST, N-terminus) (aa304-403) - LS-G58996
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
IDO1 / IDO Protein
Select
Human IDO1 / IDO Protein (Recombinant) (Ala2-Gly403) - LS-G48566
E. coli
None
SDS-PAGE
Biologically active
The recombinant human IDO1 consists of 403 amino acids and predicts a molecular mass of 45.2 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.
50 µg/$403
IDO1 / IDO Protein
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Human IDO1 / IDO Protein (Recombinant His,N-terminus) (Ala2-Gly403) - LS-G48556
E. coli
His,N-terminus
SDS-PAGE
Biologically active
The recombinant human IDO1 consisting of 409 amino acids and has a calculated molecular mass of 46 kDa. It migrates as an approximately 44 kDa band in SDS-PAGE under reducing conditions.
50 µg/$403
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Human IDO1 / IDO Protein (Recombinant His) (Ala2-Gly403) - LS-G97563
E. coli
His
46 kDa
50 µg/$710
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Human IDO1 / IDO Protein (Recombinant) (Ala2-Gly403) - LS-G97562
E. coli
None
45.2 kDa
50 µg/$710
IDO1 / IDO Protein - Recombinant Indoleamine-2,3-Dioxygenase By SDS-PAGE
Select
Mouse IDO1 / IDO Protein (Recombinant His-T7) (aa26-199) - LS-G24355
E. coli
His-T7
23.0 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
IDO1 / IDO Protein - Active Indoleamine-2,3-Dioxygenase (IDO) by WB
Select
Human IDO1 / IDO Protein (Recombinant His, N-Terminal) (aa2-403) - LS-G132778
E. coli
His, N-Terminal
43kDa
10 µg/$331; 50 µg/$752; 200 µg/$1,365; 100 µg/$1,156; 1 mg/$2,648; 500 µg/$2,144; 5 mg/$5,251; 2 mg/$2,838
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Human IDO1 / IDO Protein (Recombinant 6His, N-terminus) (Met1-Gly403) - LS-G40245
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
Mouse IDO1 / IDO Protein (Recombinant 6His, N-terminus) (Met1-Pro407) - LS-G40246
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.1kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
IDO1 / IDO Protein - 12.5% SDS-PAGE of human IDO1 stained with Coomassie Blue
Select
Human IDO1 / IDO Protein (Recombinant GST, N-terminus) (Full Length) - LS-G29062
Wheat Germ Extract
GST, N-terminus
70.07 kDa
10 µg/$479; 25 µg/$670
Select
Mouse IDO1 / IDO Protein (Recombinant 6His, N-terminus) (Met1-Pro407) - LS-G140624
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.1 kDa
10 µg/$344; 50 µg/$584
Select
Human IDO1 / IDO Protein (Recombinant 6His, N-terminus) (Met1-Gly403) - LS-G140215
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.8 kDa
10 µg/$344; 50 µg/$584
IDO1 / IDO Protein - Recombinant Indoleamine-2,3-Dioxygenase By SDS-PAGE
Select
Rat IDO1 / IDO Protein (Recombinant His) (aa106-190) - LS-G13981
E. coli
His
10.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
IDO1 / IDO Protein - Recombinant Indoleamine-2,3-Dioxygenase By SDS-PAGE
Select
Rat IDO1 / IDO Protein (Recombinant His) (aa276-360) - LS-G13982
E. coli
His
11.2 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
IDO1 / IDO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
IDO1 / IDO Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99666
HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
100 µg/$494
IDO1 / IDO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human IDO1 / IDO Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76755
293T Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$150
IDO1 / IDO Protein
Select
Human IDO1 / IDO Protein (Recombinant His) - LS-G2928
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
IDO1 / IDO Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mouse IDO1 / IDO Protein (Recombinant 6His, N-terminus) (aa1-407) - LS-G57189
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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