IDE

insulin-degrading enzyme

IDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

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Products

Antibodies (45)

ELISA Kits (21)

Proteins (9)

Type

Competitive EIA (3)

Custom (2)

Development Kit (1)

Over-Expression Lysate (2)

Primary (45)

Recombinant (7)

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Target

IDE (75)

Reactivity

Human (51)

Mouse (9)

Rat (10)

Bat (5)

Bovine (4)

Chicken (4)

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rabbit (34)

mouse (6)

goat (5)

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Epitope

aa753-973 (8)

aa406-435 (7)

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No (75)

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Plasma (13)

Serum (13)

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Mouse IDE (Sandwich ELISA) ELISA Kit - LS-F5702

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

Select

Human IDE (Sandwich ELISA) ELISA Kit - LS-F6210

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

Select

IHC-plus™ IDE Antibody (aa914-924) LS-B3954

(4.0) Rating

Antibody:

IDE Goat anti-Human Polyclonal (aa914-924) Antibody

Reactivity:

Dog, Horse, Bat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

Select

Mouse IDE (Sandwich ELISA) ELISA Kit - LS-F34737

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human IDE (Sandwich ELISA) ELISA Kit - LS-F23775

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

PathPlus™ IDE Antibody (clone 3H4) LS-B14646

Neuroscience

(5.0) Rating

Antibody:

IDE Mouse anti-Human Monoclonal (3H4) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

IDE Antibody (clone 1H4) LS-C767393

Antibody:

IDE Mouse anti-Human Monoclonal (1H4) Antibody

Reactivity:

Human

Applications:

IF, IHC-P, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

IDE Antibody LS-C662520

Antibody:

IDE Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

IDE Antibody (aa914-924) LS-C54995

Antibody:

IDE Goat anti-Mouse Polyclonal (aa914-924) Antibody

Reactivity:

Mouse, Rat, Hamster

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PathPlus™ IDE Antibody LS-B4856

Neuroscience

(5.0) Rating

Antibody:

IDE Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$440

Select

PathPlus™ IDE Antibody (aa222-233) LS-B4179

Neuroscience

(5.0) Rating

Antibody:

IDE Goat anti-Human Polyclonal (aa222-233) Antibody

Reactivity:

Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

IDE Antibody LS-C752550

Antibody:

IDE Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

Rat IDE (Sandwich ELISA) ELISA Kit - LS-F7574

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$750

Select

Mouse IDE (Sandwich ELISA) ELISA Kit - LS-F11706

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Human IDE (Sandwich ELISA) ELISA Kit - LS-F34736

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

IDE Antibody LS-C499097

Antibody:

IDE Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

IDE Antibody (HRP) LS-C499098

Antibody:

IDE Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP

• Unconjugated
• HRP

Select

IDE Antibody (aa753-973) LS-C294630

Antibody:

IDE Rabbit anti-Human Polyclonal (aa753-973) Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

Select

IDE Antibody (aa406-435) LS-C98186

Antibody:

IDE Rabbit anti-Human Polyclonal (aa406-435) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

IDE Antibody (aa406-435) LS-C327665

Antibody:

IDE Rabbit anti-Human Polyclonal (aa406-435) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

IDE Antibody (aa406-435, Biotin) LS-C278543

Antibody:

IDE Rabbit anti-Human Polyclonal (aa406-435) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

IDE Antibody (aa406-435, APC) LS-C278540

Antibody:

IDE Rabbit anti-Human Polyclonal (aa406-435) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• APC

• Unconjugated
• Biotin
• APC

Select

IDE Antibody LS-C331595

Antibody:

IDE Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$287; 100 µl/$431

Select

IDE Antibody LS-C809533

Antibody:

IDE Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

IDE Antibody (clone 3H4) LS-C781700

Antibody:

IDE Mouse anti-Human Monoclonal (3H4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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