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IAPP / Amylin

islet amyloid polypeptide

IAPP / Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity.

Gene Name: islet amyloid polypeptide
Synonyms: IAPP, Diabetes-associated peptide, Islet amyloid polypeptide, AMYLIN, IAP, Insulinoma amyloid peptide
Target Sequences: NM_000415 NP_000406.1 P10997

Publications (6)

1
Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Journal of the American Heart Association. 2014 3: (WB; Human) [Full Text Article] [PubMed:25146704] [PMC:PMC4310392] Related Antibodies: LS-C20521.
2
Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation. Ribeiro D, Horvath I, Heath N, Hicks R, Forslöw A, Wittung-Stafshede P. Proceedings of the National Academy of Sciences of the United States of America. 2017 October;114:11127-11132. [Full Text Article] [PubMed:28973954] [PMC:PMC5651775]
3
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Pietro Sormanni, Francesco A Aprile, Michele Vendruscolo. Proceedings of the National Academy of Sciences of the United States of America. 2015 August;112:9902-7. [Full Text Article] [PubMed:26216991] [PMC:PMC4538631] Related Antibodies: LS-B35.
4
Melatonin influences the expression and oligomerization of amylin in rat INS-1E cells. E-M Jung, Y-M Yoo, E-B Jeung. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 October;70: [Full Text Article] [PubMed:31889041] Related Antibodies: LS-C352341.
5
Human Islet Amyloid Polypeptide Overexpression in INS-1E Cells Influences Amylin Oligomerization under ER Stress and Oxidative Stress. Yeong-Min Yoo, Seong Soo Joo. International journal of molecular sciences. 2021 Oct;22:11341. [Full Text Article] [PubMed:34768769] [PMC:PMC8583535] Related Antibodies: LS-C352341.
6
Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Jackson K, Barisone GA, Diaz E, Jin LW, DeCarli C, Despa F. Annals of neurology. 2013 Oct;74:517-26. [Full Text Article] [PubMed:23794448] [PMC:PMC3818462] Related Antibodies: LS-C20521.
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Antibodies (64)
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IAPP / Amylin (94)
Human (68)
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IAPP / Amylin Antibody - Anti-Amylin antibody IHC of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IAPP / Amylin Mouse anti-Human Monoclonal (Supernatant) (R10/99) Antibody
Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated, Supernatant
0.05 ml/$555
IAPP / Amylin Antibody - Immunohistochemical analysis of Amylin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IAPP / Amylin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
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IAPP / Amylin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$801
IAPP / Amylin Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IAPP / Amylin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IAPP / Amylin Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Amylin Antibody. The picture on the right is blocked with the synthesized peptide.
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IAPP / Amylin Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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IAPP / Amylin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$801
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IAPP / Amylin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
IAPP / Amylin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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IAPP / Amylin Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Cat
IF, IHC
Unconjugated
50 µl/$572
IAPP / Amylin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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IAPP / Amylin Rabbit anti-Human Polyclonal Antibody
Guinea pig, Rat, Pig, Cat, Human
IHC, IHC-Fr, IHC-P
Unconjugated
50 µl/$1,130
IAPP / Amylin Antibody - Immunohistochemistry of paraffin-embedded human pancreatic tissue using Rabbit anti-human Islet amyloid polypeptide polyclonal Antibody at dilution of 1:100
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IAPP / Amylin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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IAPP / Amylin Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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IAPP / Amylin Rabbit anti-Human Polyclonal (C-term) Antibody
Human
ELISA, WB
Unconjugated
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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IAPP / Amylin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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IAPP / Amylin Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
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IAPP / Amylin Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
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IAPP / Amylin Rabbit anti-Human Polyclonal (aa1-13) Antibody
Human
ELISA
Unconjugated
100 µg/$755
IAPP / Amylin Antibody - 1:100 staining human pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IAPP / Amylin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IAPP / Amylin Antibody - IHC of Amylin (H28) pAb in paraffin-embedded human brain pancreas tissue.
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IAPP / Amylin Rabbit anti-Human Polyclonal (His28) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Viewing 1-25 of 94 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).