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Human IgA

Immunoglobulin A (IgA, also referred to as sIgA) is an antibody that plays a critical role in mucosal immunity. More IgA is produced in mucosal linings than all other types of antibody combined; between three and five grams are secreted into the intestinal lumen each day. This accumulates up to 15% of the total immunoglobulin produced in the entire body. IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). In its secretory form, IgA is the main immunoglobulin found in mucous secretions, including tears, saliva, sweat, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood. The secretory component of sIgA protects the immunoglobulin from being degraded by proteolytic enzymes, thus sIgA can survive in the harsh gastrointestinal tract environment and provide protection against microbes that multiply in body secretions. sIgA can also inhibit inflammatory effects of other immunoglobulins. IgA is a poor activator of the complement system, and opsonises only weakly. Its heavy chains are of the type alpha.

Human IgA Target Details

Target Name: Human IgA

Publications (1)

1
Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8? T cells responding to infection. Bergsbaken T, Bevan MJ. Nature immunology. 2015 16:406-14. (ELISA; Human) [Full Text Article] [PubMed:25706747] [PMC:PMC4368475]

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Antibodies (156)
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Human IgA (163)
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Human IgA Antibody - Anti-IgA antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Human IgA Mouse anti-Human Monoclonal (Mc24-2E11) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$460
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Human IgA Rabbit anti-Human Polyclonal (HRP) Antibody
Rabbit, Human
ELISA, IHC, WB
HRP Conjugated
1 mg/$606
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Human IgA Goat anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IF
FITC Conjugated
1 mg/$522
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Human IgA Rabbit anti-Human Polyclonal (Rhodamine) Antibody
Human
ELISA, IP, WB
Rhodamine Conjugated
500 µg/$457
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Human
None
0.5 mg/$467
Human IgA ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Saliva, Serum
1 Plate/$685
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Human IgA Goat anti-Human Polyclonal (Fab'2) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated, Fab'2
0.5 mg/$281
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Human IgA Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
1 mg/$320
Human IgA Antibody - Flow cytometry of Human IgA antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Human IgA Mouse anti-Human Monoclonal (Biotin) (Hisa43) Antibody
Human
ELISA, Flo
Biotin Conjugated
100 µg/$446
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Human IgA Goat anti-Human Polyclonal (FITC) Antibody
Human
ELISA, Flo, ID, IF, IHC, IP, WB
FITC Conjugated
1 mg/$328
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Human IgA Mouse Monoclonal (HRP) Antibody
Human
ELISA, IF, IHC, WB
HRP Conjugated
100 µl/$431
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Human IgA Goat anti-Human Polyclonal (Fab'2) (PE) Antibody
Human
FLISA, Flo
PE Conjugated, Fab'2
0.25 mg/$448
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Human IgA Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
200 µg/$672
Human IgA ELISA Kit
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Sandwich
96-Well Microplate
Human
0.24 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$563
Human IgA Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Human IgA Mouse anti-Human Monoclonal (NI 69 (A89-034) and NI 184 (A89-035)) Antibody
Human
ELISA, IF, IHC-P
Unconjugated
0.5 mg/$485
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Human IgA Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, ICC, IHC, WB
Biotin Conjugated
1 ml/$305
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Human IgA Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
1 ml/$883
Human IgA Antibody - Dot Blot of Human IgA (alpha chain) Antibody Fluorescein Conjugated. Antigen: Human IgA. Load: Lane 1 - 50 ng Lane 2 - 16.67 ng Lane 3 - 5.56 ng Lane 4 - 1.85 ng Lane 5 - 0.62 ng. Primary antibody: none. Secondary antibody: Human IgA (alpha chain) Antibody Fluorescein Conjugated at 1:1,000 for 60 min at RT.
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Human IgA Rabbit anti-Human Polyclonal (FITC) Antibody
Human
DB, FLISA, Flo, IF
FITC Conjugated
1 mg/$333
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Human IgA Goat anti-Human Polyclonal (TRITC) Antibody
Human
FLISA, Flo, IF
TRITC Conjugated
1 mg/$310
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Human IgA Goat anti-Human Polyclonal (Fab'2) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Fab'2
500 µl/$634
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Human IgA Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
1 ml/$290
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Human IgA Goat anti-Human Polyclonal (PE) Antibody
Human
FLISA, Flo
PE Conjugated
0.5 mg/$400
Human IgA Antibody - lgA Antibody (Ascites)western blot of CEM cell line lysates (35 ug/lane). The lgA antibody detected the lgA protein (arrow).
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Human IgA Mouse anti-Human Monoclonal (aa150-178) Antibody
Human
WB
Unconjugated
0.1 ml/$393
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Human IgA Mouse anti-Human Monoclonal (IA761) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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Human IgA Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM187) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
Viewing 1-25 of 163 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).