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HTR4 / 5-HT4 Receptor

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop.

Gene Name: 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Family/Subfamily: GPCR , Serotonin
Synonyms: HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5HT4 receptor, 5-HT4 receptor, 5-hydroxytryptamine 4 receptor, 5-hydroxytryptamine receptor 4, Serotonin 5-HT-4a receptor, Serotonin receptor 4, Cardiac 5-HT4 receptor, Serotonin 4 receptor, Serotonin 5-HT-4 receptor
Target Sequences: NM_000870 NP_000861.1 Q13639

Publications (2)

1
Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Louiset E, Duparc C, Lenglet S, Gomez-Sanchez CE, Lefebvre H. Molecular and cellular endocrinology. 2017 February;441:99-107. (Human) [Full Text Article] [PubMed:27743992] [PMC:PMC5465225] Related Antibodies: LS-A2685.
2
Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. Le Mestre J, Duparc C, Reznik Y, Bonnet-Serrano F, Touraine P, Chabre O, Young J, Suzuki M, Sibony M, Gobet F, Stratakis CA, Raverot G, Bertherat J, Lefebvre H, Louiset E. The Journal of clinical endocrinology and metabolism. 2019 November;104:4967-4980. [Full Text Article] [PubMed:31074783] [PMC:PMC6937520] Related Antibodies: LS-A2685.

☰ Filters
Antibodies (39)
Proteins (7)
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HTR4 / 5-HT4 Receptor (47)
Human (40)
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Chimpanzee (3)
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IHC (9)
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ICC (5)
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rabbit (37)
mouse (1)
rabbit-new zealand white (1)
Product Group
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IHCPlus (2)
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monoclonal mc (1)
polyclonal pc (38)
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Unconjugated (24)
aa1-30 (7)
aa144-193 (4)
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40-120 aa, N-terminal (1)
Asn180 (1)
Asp47 (1)
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aa131-180 (1)
aa141-190 (1)
aa21-70 (1)
No (46)
Yes (1)
Tissue Homogenates (1)
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293T Cells (3)
HEK 293 Cells (3)
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Purified (1)
HTR4 / 5-HT4 Receptor Antibody - Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50 µg/$460
HTR4 / 5-HT4 Receptor Antibody - Western blot of SR-4 antibody
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HTR4 / 5-HT4 Receptor Antibody - Anti-5HT4 Receptor antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
HTR4 / 5-HT4 Receptor Antibody - Immunofluorescence analysis of HeLa cells, using 5-HT-4 Antibody. The picture on the right is blocked with the synthesized peptide.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa21-70) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR4 / 5-HT4 Receptor Antibody - Immunofluorescence analysis of MCF7 cells, using HTR4 Antibody. The picture on the right is blocked with the synthesized peptide.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa141-190) Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR4 / 5-HT4 Receptor Antibody - HTR4 / 5-HT34 antibody Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
WB
Unconjugated
100 µl/$424
HTR4 / 5-HT4 Receptor Antibody - IHC of SR-4 (D47) pAb in paraffin-embedded human brain tissue.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Asp47) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
HTR4 / 5-HT4 Receptor Antibody - Immunohistochemistry image of paraffin-embedded human brain tissue at a dilution of 1:100
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HTR4 / 5-HT4 Receptor Antibody - Peptide - + Immunofluorescence analysis of MCF-7 cells, using HTR4 antibody.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
HTR4 / 5-HT4 Receptor Antibody - Peptide - + Immunofluorescence analysis of HeLa cells, using 5-HT-4 antibody.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
HTR4 / 5-HT4 Receptor Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HTR4 / 5-HT4 Receptor Antibody - Western blot of SR-4 (N180) pAb in extracts from NIH-3T3 cells.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Asn180) Antibody
Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
HTR4 / 5-HT4 Receptor Antibody - IHC-P on paraffin sections of mouse heart. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 ml 4% FA being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered through 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromogen. Primary antibody: dilution 1:1000, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.
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HTR4 / 5-HT4 Receptor Rabbit-New Zealand White anti-Human Polyclonal Antibody
Mouse, Human, Marmoset
IHC-P, WB
Unconjugated
100 µl/$393
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
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HTR4 / 5-HT4 Receptor Mouse anti-Human Monoclonal (11n173) Antibody
Human
IHC
Unconjugated
100 µg/$884
HTR4 / 5-HT4 Receptor Antibody - Western blot analysis of 5-HT4 expression in HeLa (A); Jurkat (B) whole cell lysates.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Bovine, Pig, Human
IP, WB
Unconjugated
100 µl/$299
HTR4 / 5-HT4 Receptor Antibody - Western blot analysis of the lysates from HepG2 cells using HTR4 antibody.
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HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa131-180) Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 47 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).