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| Catalog Number | Size | Price |
|---|---|---|
| LS-A2685-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human HTR4 / 5‑HT4 Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A2685
PathPlus™ Polyclonal Rabbit anti‑Human HTR4 / 5‑HT4 Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A2685
Antibody:
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Bovine, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Bovine, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
5-HT4 receptor (HTR4) is a member of the Serotonin Receptor subfamily and has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human HTR4 / 5-HT4 Receptor
Synonyms
HTR4 | 5-HT4 | 5-HT4R | 5-HT-4 | 5HT4 receptor | 5-HT4 receptor | 5-hydroxytryptamine 4 receptor | 5-hydroxytryptamine receptor 4 | Serotonin 5-HT-4a receptor | Serotonin receptor 4 | Cardiac 5-HT4 receptor | Serotonin 4 receptor | Serotonin 5-HT-4 receptor
Host
Rabbit
Reactivity
Human, Monkey, Bat, Bovine, Dog, Horse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from 3rd cytoplasmic domain of human 5HT4 Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Bovine, Rabbit, Horse, Pig (100%); Mouse, Rat, Hamster (93%); Guinea pig, Platypus (87%); Lizard (80%).
Epitope
Cytoplasmic Domain
Specificity
Human 5HT4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (15 - 20 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About HTR4 / 5-HT4 Receptor
Validation
Brain, Medulla
Brain, Medulla
Brain, Basal Ganglia
Brain, Basal Ganglia
Anti-5HT4 Receptor antibody IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT4 Receptor antibody IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain) for IHC LS-A2685 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Louiset E, Duparc C, Lenglet S, Gomez-Sanchez CE, Lefebvre H. Molecular and cellular endocrinology. 2017 February;441:99-107. (Human)
Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. Le Mestre J, Duparc C, Reznik Y, Bonnet-Serrano F, Touraine P, Chabre O, Young J, Suzuki M, Sibony M, Gobet F, Stratakis CA, Raverot G, Bertherat J, Lefebvre H, Louiset E. The Journal of clinical endocrinology and metabolism. 2019 November;104:4967-4980.
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Rat
Applications:
Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse, Rat
Applications:
Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Monkey, Horse, Pig
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/12/2024
Date Requested: 11/12/2024
