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HSPA8 / HSC70
heat shock 70kDa protein 8
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
| Gene Name: | heat shock 70kDa protein 8 |
| Synonyms: | HSPA8, Heat shock 70 kDa protein 8, Heat shock 70kd protein 10, Heat shock 70kD protein 8, Heat shock cognate protein 54, HSP71, HSPA10, HSC71, HSP73, LPS-associated protein 1, Heat shock 70kDa protein 8, NIP71, HSC54, HSC70, LAP1 |
| Target Sequences: | NM_006597 NP_006588.1 P11142 |
Publications (1)
1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster)
[Full Text Article]
[PubMed:28694505]
[PMC:PMC5504025]
Related Antibodies: LS-C63254.
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Antibodies
(142)
Type
Primary
(142)
Target
HSPA8 / HSC70
(142)
Reactivity
Human
(104)
Mouse
(73)
Rat
(79)
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(5)
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(9)
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(37)
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(30)
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(3)
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(8)
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(26)
Drosophila
(16)
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(9)
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(27)
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(14)
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(5)
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(12)
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Publications
No
(141)
Yes
(1)
HSPA8 / HSC70 Rat anti-Hamster Monoclonal (PE) (1B5) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
Flo
PE Conjugated
100 µg/$538
HSPA8 / HSC70 Rat anti-Hamster Monoclonal (Biotin) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Pig, Human
ELISA, Flo, ICC, IHC, IP, WB
Biotin Conjugated
50 µg/$582; 200 µg/$995
HSPA8 / HSC70 Mouse anti-Human Monoclonal (1F2-H5) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µg/$325; 200 µg/$465
HSPA8 / HSC70 Mouse anti-Human Monoclonal (APC) (1F2-H5) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
200 µg/$533
HSPA8 / HSC70 Mouse anti-Human Monoclonal (1F2-H5) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$461
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa618-637) Antibody
Mouse, Hamster, Human
Block, ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
HSPA8 / HSC70 Goat anti-Human Polyclonal (Isoform 1) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
HSPA8 / HSC70 Mouse anti-Human Monoclonal (Internal) (6C7) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa82-110) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
HSPA8 / HSC70 Rat anti-Hamster Monoclonal Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
ICC, IHC, IP, WB
Unconjugated
50 µg/$481; 200 µg/$717
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa520-614) Antibody
Rabbit, Mouse, Goat, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
HSPA8 / HSC70 Mouse anti-Chicken Monoclonal (BB70) Antibody
IHC, IP, WB
Unconjugated
50 µg/$313; 200 µg/$430
HSPA8 / HSC70 Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$445
HSPA8 / HSC70 Rat anti-Hamster Monoclonal (1B5) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$535
HSPA8 / HSC70 Mouse anti-Human Monoclonal (OTI1H3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HSPA8 / HSC70 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H3) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HSPA8 / HSC70 Rat anti-Human Monoclonal Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Human, Monkey
Flo, ICC, IHC, IP, WB
Unconjugated
50 µg/$611; 200 µg/$1,001
HSPA8 / HSC70 Rabbit anti-Cow Polyclonal (aa534-615) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$328; 200 µl/$379; 500 µl/$547; 1 ml/$648; 2 ml/$883; 5 ml/$1,471
HSPA8 / HSC70 Mouse anti-Chicken Monoclonal Antibody
Xenopus, Chicken, Drosophila, Pig, Rat, Hamster, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Yeast
ELISA, ICC, IHC, IP, WB
Unconjugated
50 µg/$540; 200 µg/$820
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa143-192) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa650-670) Antibody
Hamster, Human
IF, IHC, IP, WB
Unconjugated
25 µl/$307; 100 µl/$418
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Bovine, Rat, Pig, Mouse, Human, Monkey
ICC, IF, IP, WB
Unconjugated
100 µl/$299
HSPA8 / HSC70 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
HSPA8 / HSC70 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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product results
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