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HSPA8 / HSC70
heat shock 70kDa protein 8
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
| Gene Name: | heat shock 70kDa protein 8 |
| Synonyms: | HSPA8, Heat shock 70 kDa protein 8, Heat shock 70kd protein 10, Heat shock 70kD protein 8, Heat shock cognate protein 54, HSP71, HSPA10, HSC71, HSP73, LPS-associated protein 1, Heat shock 70kDa protein 8, NIP71, HSC54, HSC70, LAP1 |
| Target Sequences: | NM_006597 NP_006588.1 P11142 |
Publications (1)
1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster)
[Full Text Article]
[PubMed:28694505]
[PMC:PMC5504025]
Related Antibodies: LS-C63254.
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HSPA8 / HSC70 Rat anti-Hamster Monoclonal (PE) (1B5) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
Flo
PE Conjugated
100 µg/$538
HSPA8 / HSC70 Rat anti-Hamster Monoclonal (Biotin) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Pig, Human
ELISA, Flo, ICC, IHC, IP, WB
Biotin Conjugated
50 µg/$582; 200 µg/$995
HSPA8 / HSC70 Mouse anti-Human Monoclonal (1F2-H5) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µg/$325; 200 µg/$465
HSPA8 / HSC70 Mouse anti-Human Monoclonal (APC) (1F2-H5) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
200 µg/$533
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$685
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
HEK 293 Cells
His, N-Terminal
71 kDa
10 µg/$289
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$705
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
HSPA8 / HSC70 Mouse anti-Human Monoclonal (1F2-H5) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$461
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa618-637) Antibody
Mouse, Hamster, Human
Block, ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
HSPA8 / HSC70 Goat anti-Human Polyclonal (Isoform 1) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
HSPA8 / HSC70 Mouse anti-Human Monoclonal (Internal) (6C7) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa82-110) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
His
100 µg/$511; 500 µg/$1,348; 20 µg/$311
HSPA8 / HSC70 Rat anti-Hamster Monoclonal Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
ICC, IHC, IP, WB
Unconjugated
50 µg/$481; 200 µg/$717
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa520-614) Antibody
Rabbit, Mouse, Goat, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
HSPA8 / HSC70 Mouse anti-Chicken Monoclonal (BB70) Antibody
IHC, IP, WB
Unconjugated
50 µg/$313; 200 µg/$430
HSPA8 / HSC70 Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Drosophila, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
HSPA8 / HSC70 Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$445
HSPA8 / HSC70 Rat anti-Hamster Monoclonal (1B5) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$535
HSPA8 / HSC70 Mouse anti-Human Monoclonal (OTI1H3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HSPA8 / HSC70 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H3) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HSPA8 / HSC70 Rat anti-Human Monoclonal Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Human, Monkey
Flo, ICC, IHC, IP, WB
Unconjugated
50 µg/$611; 200 µg/$1,001
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