HPSE / Heparanase

heparanase

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

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Products

Proteins (15)

Type

Over-Expression Lysate (4)

Recombinant (11)

Target

HPSE / Heparanase (15)

Publications

No (15)

Tag

GST, N-terminus (1)

His (8)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (8)

Mouse (4)

Rat (1)

Source

293T Cells (2)

E. coli (10)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Mouse HPSE / Heparanase Protein (Recombinant His) (aa419-535) - LS-G12689

Source:

E. coli

Tag:

His

Molecular Weight:

14.6 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Human HPSE / Heparanase Protein (Recombinant His) - LS-G2784

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human HPSE / Heparanase Protein (Recombinant GST, N-terminus) (aa72-170) - LS-G61661

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HPSE / Heparanase Protein (Recombinant His) (aa400-543) - LS-G12681

Source:

E. coli

Tag:

His

Molecular Weight:

17.9 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Human HPSE / Heparanase Protein (Recombinant His) (aa54-278) - LS-G12683

Source:

E. coli

Tag:

His

Molecular Weight:

27.3 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Human HPSE / Heparanase Protein (Recombinant His) (aa34-115) - LS-G12684

Source:

E. coli

Tag:

His

Molecular Weight:

10.7 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Mouse HPSE / Heparanase Protein (Recombinant His) (aa280-412) - LS-G12686

Source:

E. coli

Tag:

His

Molecular Weight:

16.4 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Mouse HPSE / Heparanase Protein (Recombinant His) (aa27-101) - LS-G12690

Source:

E. coli

Tag:

His

Molecular Weight:

9.9 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Mouse HPSE / Heparanase Protein (Recombinant His) (aa353-464) - LS-G12692

Source:

E. coli

Tag:

His

Molecular Weight:

14.5 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Rat HPSE / Heparanase Protein (Recombinant His-T7) (aa40-188) - LS-G24097

Source:

E. coli

Tag:

His-T7

Molecular Weight:

20.9 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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HPSE / Heparanase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100876

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

100 µg/$494

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Human HPSE / Heparanase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83508

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

20 µg/$215

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Human HPSE / Heparanase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83510

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

20 µg/$150

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HPSE / Heparanase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119263

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

100 µg/$710

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Human HPSE / Heparanase Protein (Recombinant His, N-Terminal) - LS-G144312

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

61 kDa

Price:

50 µg/$419

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