HPSE / Heparanase

heparanase

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

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Products

ELISA Kits (20)

Type

Competitive EIA (3)

Custom (2)

Development Kit (1)

Sandwich (13)

Sandwich CLIA (1)

Target

HPSE / Heparanase (20)

Reactivity

Human (7)

Mouse (6)

Rat (5)

Chicken (1)

Product Group

DevKit DuoPlus (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (15)

Antibody Pair and Standard (1)

Publications

No (20)

Sample Type

Cell Culture Supernatants (4)

Cell Lysates (4)

Plasma (18)

Serum (18)

Tissue Homogenates (8)

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Human HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F4764

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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Mouse HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F11657

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Human HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F21251

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F6631

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Rat HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F11658

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F9070

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$715

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Mouse HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F55959

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F56498

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human HPSE / Heparanase (Competitive EIA) ELISA Kit - LS-F27707

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

100 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F54929

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

Select

DevKit DuoPlus Human HPSE / Heparanase ELISA Development Kit - LS-F71639

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

62.4 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,182; 1000 Wells/$1,747

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Chicken HPSE / Heparanase (Custom ELISA) ELISA Kit - LS-F15082

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine HPSE / Heparanase (Custom ELISA) ELISA Kit - LS-F15083

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F24044

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Rat HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F24075

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse HPSE / Heparanase (CLIA) ELISA Kit - LS-F30768

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Human HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F35071

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse HPSE / Heparanase (Competitive EIA) ELISA Kit - LS-F28404

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Rat HPSE / Heparanase (Competitive EIA) ELISA Kit - LS-F27988

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human HPSE / Heparanase (Sandwich ELISA) ELISA Kit - LS-F40141

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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