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HMBS / PBGD

hydroxymethylbilane synthase

HMBS / PBGD is a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene Name: hydroxymethylbilane synthase
Synonyms: HMBS, Hydroxymethylbilane synthase, PBG-D, PBGD, PORC, Porphyria, acute Chester type, Porphobilinogen deaminase, Pre-uroporphyrinogen synthase, UPS, Uroporphyrinogen I synthetase, Uroporphyrinogen I synthase
Target Sequences: NM_000190 NP_000181.2 P08397

☰ Filters
Products
Antibodies (50)
Primary (50)
HMBS / PBGD (50)
Human (50)
Mouse (10)
Rat (8)
Bat (3)
Bovine (3)
Chimpanzee (6)
Dog (3)
Gibbon (6)
Guinea pig (6)
Horse (3)
Monkey (6)
Pig (11)
Rabbit (6)
Xenopus (3)
Zebrafish (3)
IHC (8)
IHC-P (1)
WB (46)
ELISA (9)
IF (5)
IP (2)
Peptide-ELISA (2)
rabbit (36)
mouse (13)
goat (1)
Product Group
IHCPlus (1)
IgG (21)
IgG1 (12)
IgG2a,k (1)
monoclonal mc (13)
polyclonal pc (37)
3E8 (1)
OTI1F1 (2)
OTI2F4 (2)
OTI3E2 (2)
OTI3F4 (2)
OTI5B11 (2)
UMAB144 (2)
APC (1)
APC Conjugated (1)
Biotin Conjugated (5)
Carrier-free (6)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (1)
Unconjugated (31)
aa85-337 (8)
C-Terminus (4)
N-Terminus (4)
aa146-195 (4)
aa311-361 (1)
aa84-352 (1)
No (50)
HMBS / PBGD Antibody - Western blot analysis of extracts of various cell lines.
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
HMBS / PBGD Antibody - Western blot analysis of HMBS using anti-HMBS antibody
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
HMBS / PBGD Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using HMBS Antibody at dilution of 1:100
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
HMBS / PBGD Antibody - Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-HMBS mouse monoclonal antibody.  heat-induced epitope retrieval by 10mM citric buffer, pH9.0, 120C for 3min)
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HMBS / PBGD Mouse anti-Human Monoclonal (UMAB144) Antibody
Human
IF, IHC, WB
Unconjugated
100 µl/$493
HMBS / PBGD Antibody - Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-HMBS mouse monoclonal antibody.  heat-induced epitope retrieval by 10mM citric buffer, pH9.0, 120C for 3min)
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HMBS / PBGD Mouse anti-Human Monoclonal (Carrier-free) (UMAB144) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$539
HMBS / PBGD Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HMBS / PBGD Goat anti-Human Polyclonal Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
HMBS / PBGD Antibody - Western blot analysis of HeLa whole cells lysates using HMBS antibody. The lane on the left is treated with the antigen-specific peptide.
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$331
HMBS / PBGD Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using HMBS Polyclonal Antibody at dilution of 1:25(×200)
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HMBS / PBGD Antibody - Western blot of extracts of HeLa cell lines, using HMBS antibody.
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
HMBS / PBGD Antibody - Western Blot analysis of HMBS expression in transfected 293T cell line by HMBS monoclonal antibody (M01), clone 3E8.Lane 1: HMBS transfected lysate(39.71 KDa).Lane 2: Non-transfected lysate.
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HMBS / PBGD Mouse anti-Human Monoclonal (3E8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
HMBS / PBGD Antibody - Western blot analysis of K562 cell lysate  using HMBS Polyclonal Antibody at dilution of 1:450
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HMBS / PBGD Antibody - Detection of Human HMBS by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-HMBS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
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HMBS / PBGD Rabbit anti-Human Polyclonal (aa311-361) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
HMBS / PBGD Antibody - Anti-HMBS rabbit polyclonal antibody at 1:500 dilution. Lane A: HepG2 Whole Cell Lysate. Lane B: HeLa Whole Cell Lysate. Lane C: U937 Whole Cell Lysate. Lane D: K562 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 39 kDa. Observed band size: 45 kDa.
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HMBS / PBGD Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$412
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (OTI1F1) Antibody
Human
WB
Unconjugated
100 µl/$434
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (Carrier-free) (OTI1F1) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (OTI5B11) Antibody
Human
WB
Unconjugated
100 µl/$434
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (Carrier-free) (OTI5B11) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (OTI3F4) Antibody
Human
WB
Unconjugated
100 µl/$434
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (Carrier-free) (OTI3F4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (OTI3E2) Antibody
Human
WB
Unconjugated
100 µl/$434
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (Carrier-free) (OTI3E2) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (OTI2F4) Antibody
Human
WB
Unconjugated
100 µl/$434
HMBS / PBGD Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HMBS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HMBS.
Select
HMBS / PBGD Mouse anti-Human Monoclonal (Carrier-free) (OTI2F4) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
Select
HMBS / PBGD Rabbit anti-Human Polyclonal (aa84-352) Antibody
Human
WB
Unconjugated
100 µl/$450
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).