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HIF2A / EPAS1

endothelial PAS domain protein 1

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Gene Name: endothelial PAS domain protein 1
Synonyms: EPAS1, BHLHe73, ECYT4, HIF-1-alpha-like factor, HIF2-alpha, HIF2A, EPAS-1, HIF-2-alpha, HIF-1alpha-like factor, MOP2, Member of PAS protein 2, PASD2
Target Sequences: NM_001430 NP_001421.2 Q99814

Publications (254)

1
[Fibroxanthoma retroperitonei]. Biernat S. Wiadomoci lekarskie (Warsaw, Poland : 1960). 1976 29:845-8. (WB; Human) [PubMed:1274359]
2
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH. Blood. 1998 92:2260-8. [PubMed:9746763]
3
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. Conrad PW, Freeman TL, Beitner-Johnson D, Millhorn DE. The Journal of biological chemistry. 1999 274:33709-13. (WB; Mouse) [PubMed:10559262]
4
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. Nature cell biology. 2000 2:423-7. [PubMed:10878807]
5
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Rajakumar A, Conrad KP. Biology of reproduction. 2000 63:559-69. [PubMed:10906065]
6
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The American journal of pathology. 2000 157:411-21. (IHC, WB, IHC-P; Human) [PubMed:10934146] [PMC:PMC1850121]
7
Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. Bonicalzi ME, Groulx I, de Paulsen N, Lee S. The Journal of biological chemistry. 2001 276:1407-16. [PubMed:11024059]
8
Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Blancher C, Moore JW, Talks KL, Houlbrook S, Harris AL. Cancer research. 2000 60:7106-13. (IHC, WB) [PubMed:11156418]
9
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S. Proceedings of the National Academy of Sciences of the United States of America. 2001 98:1387-92. (WB, Flo; Human) [PubMed:11171960] [PMC:PMC29266]
10
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Haase VH, Glickman JN, Socolovsky M, Jaenisch R. Proceedings of the National Academy of Sciences of the United States of America. 2001 98:1583-8. [PubMed:11171994] [PMC:PMC29300]
11
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Koukourakis MI, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, Gatter KC, Harris AL. Cancer research. 2001 61:1830-2. (IHC-P; Human) [PubMed:11280732]
12
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. Alvarez-Tejado M, Naranjo-Suarez S, Jimnez C, Carrera AC, Landzuri MO, del Peso L. The Journal of biological chemistry. 2001 276:22368-74. (WB; Mouse) [PubMed:11294857]
13
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Luo JC, Shibuya M. Oncogene. 2001 20:1435-44. [PubMed:11313887]
14
Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ad N, Snir E, Vidne BA, Golomb E. The Annals of thoracic surgery. 2001 72:688-93. [PubMed:11565642]
15
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, Harris AL. Cancer research. 2001 61:7992-8. (IHC-P; Human) [PubMed:11691824]
16
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L. Nature. 2001 414:550-4. [PubMed:11734856]
17
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J. The Journal of biological chemistry. 2002 277:6183-7. [PubMed:11744734]
18
Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M, Lewis CE. The Journal of pathology. 2002 196:204-12. [PubMed:11793372]
19
Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. Alvarez-Tejado M, Alfranca A, Aragons J, Vara A, Landzuri MO, del Peso L. The Journal of biological chemistry. 2002 277:13508-17. (WB; Human) [PubMed:11815624]
20
Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. Liang Y, Li XY, Rebar EJ, Li P, Zhou Y, Chen B, Wolffe AP, Case CC. The Journal of biological chemistry. 2002 277:20087-94. [PubMed:11912213]
21
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL. Cancer research. 2002 62:2493-7. (IHC-P; Human) [PubMed:11980639]
22
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K. Urology. 2002 59:774-8. [PubMed:11992927]
23
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG. Cancer cell. 2002 1:237-46. [PubMed:12086860]
24
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. Cancer cell. 2002 1:247-55. [PubMed:12086861]
25
Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR. The Journal of biological chemistry. 2002 277:39728-38. [PubMed:12145288]
26
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. The Journal of biological chemistry. 2002 277:40112-7. [PubMed:12186875]
27
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC. Cancer cell. 2003 3:75-88. [PubMed:12559177]
28
Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. Yuan Y, Hilliard G, Ferguson T, Millhorn DE. The Journal of biological chemistry. 2003 278:15911-6. [PubMed:12606543]
29
Induction of T-type calcium channel gene expression by chronic hypoxia. Del Toro R, Levitsky KL, Lpez-Barneo J, Chiara MD. The Journal of biological chemistry. 2003 278:22316-24. [PubMed:12679337]
30
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Graven KK, Bellur D, Klahn BD, Lowrey SL, Amberger E. Biochimica et biophysica acta. 2003 1626:8-Oct. [PubMed:12697324]
31
Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Khatua S, Peterson KM, Brown KM, Lawlor C, Santi MR, LaFleur B, Dressman D, Stephan DA, MacDonald TJ. Cancer research. 2003 63:1865-70. [PubMed:12702575]
32
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P. Cancer cell. 2003 3:363-75. [PubMed:12726862]
33
Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. Naranjo-Surez S, Castellanos MC, Alvarez-Tejado M, Vara A, Landzuri MO, del Peso L. The Journal of biological chemistry. 2003 278:31895-901. [PubMed:12805361]
34
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Molecular and cellular biology. 2003 23:4959-71. [PubMed:12832481] [PMC:PMC162224]
35
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H, Simons JW. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:2416-25. [PubMed:12855613]
36
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Palayoor ST, Tofilon PJ, Coleman CN. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:3150-7. [PubMed:12912967]
37
von Hippel-Lindau protein complex is regulated by cell density. Mohan S, Burk RD. Oncogene. 2003 22:5270-80. (WB) [PubMed:12917628]
38
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Nature. 2003 425:307-11. [PubMed:13679920]
39
The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO. The Journal of biological chemistry. 2003 278:48690-5. [PubMed:14506252]
40
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Corn PG, McDonald ER, Herman JG, El-Deiry WS. Nature genetics. 2003 35:229-37. [PubMed:14556007]
41
Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cuevas Y, Hernndez-Alcoceba R, Aragones J, Naranjo-Surez S, Castellanos MC, Esteban MA, Martn-Puig S, Landazuri MO, del Peso L. Cancer research. 2003 63:6877-84. [PubMed:14583486]
42
Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. Martn-Puig S, Temes E, Olmos G, Jones DR, Aragons J, Landzuri MO. The Journal of biological chemistry. 2004 279:9504-11. [PubMed:14681229]
43
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C. The Journal of biological chemistry. 2004 279:14871-8. [PubMed:14744852]
44
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Molecular cancer research : MCR. 2004 2:89-95. (WB) [PubMed:14985465]
45
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Cancer research. 2004 64:1765-72. [PubMed:14996738]
46
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G. Molecular cancer therapeutics. 2004 3:233-44. [PubMed:15026543]
47
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, Suga T, Iso T, Ohyama Y, Arai M, Tamura J, Sakamoto H, Nagai R, Kurabayashi M. American journal of respiratory cell and molecular biology. 2004 31:209-15. [PubMed:15039136]
48
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Pan Y, Oprysko PR, Asham AM, Koch CJ, Simon MC. Oncogene. 2004 23:4975-83. [PubMed:15107830]
49
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L. American journal of physiology. Lung cellular and molecular physiology. 2004 287:L525-32. [PubMed:15132953]
50
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R, Kanangi R. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:8132-7. [PubMed:15141079] [PMC:PMC419569]
51
Oxygen-regulated gene expression in bovine blastocysts. Harvey AJ, Kind KL, Pantaleon M, Armstrong DT, Thompson JG. Biology of reproduction. 2004 71:1108-19. [PubMed:15163614]
52
HIF activation by pH-dependent nucleolar sequestration of VHL. Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S. Nature cell biology. 2004 6:642-7. [PubMed:15181450]
53
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, Oosterwijk E. Oncogene. 2004 23:5624-31. (Human) [PubMed:15184875]
54
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Takeda N, Maemura K, Imai Y, Harada T, Kawanami D, Nojiri T, Manabe I, Nagai R. Circulation research. 2004 95:146-53. [PubMed:15192019]
55
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Molecular and cellular biology. 2004 24:9038-47. [PubMed:15456877] [PMC:PMC517905]
56
Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. Freeburg PB, Abrahamson DR. Journal of the American Society of Nephrology : JASN. 2004 15:2569-78. [PubMed:15466261]
57
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Cancer cell. 2004 6:485-95. [PubMed:15542432]
58
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Rathmell WK, Hickey MM, Bezman NA, Chmielecki CA, Carraway NC, Simon MC. Cancer research. 2004 64:8595-603. [PubMed:15574766]
59
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. Miller F, Kentsis A, Osman R, Pan ZQ. The Journal of biological chemistry. 2005 280:7985-96. [PubMed:15611064]
60
Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 10:8554-60. [PubMed:15623639]
61
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. Temes E, Martn-Puig S, Acosta-Iborra B, Castellanos MC, Feijoo-Cuaresma M, Olmos G, Aragons J, Landazuri MO. The Journal of biological chemistry. 2005 280:24238-44. [PubMed:15849364]
62
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S. Cancer research. 2005 65:5221-30. [PubMed:15958567]
63
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Gnzler V, White CW. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:10212-7. (WB; Human) [PubMed:16009933] [PMC:PMC1177409]
64
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW, Shen Y. Cancer research. 2005 65:7249-58. (IHC, WB) [PubMed:16103076]
65
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia. Eul B, Rose F, Krick S, Savai R, Goyal P, Klepetko W, Grimminger F, Weissmann N, Seeger W, Hnze J. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:163-5. [PubMed:16263938]
66
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G. Blood. 2006 107:2705-12. [PubMed:16304044] [PMC:PMC1895390]
67
Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Schultz K, Fanburg BL, Beasley D. American journal of physiology. Heart and circulatory physiology. 2006 290:H2528-34. [PubMed:16399861]
68
Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O, Kotani H, Manabe T, Zhang GJ, Kondo K, Nos V, Kaelin WG. The American journal of pathology. 2006 168:574-84. [PubMed:16436671] [PMC:PMC1606480]
69
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Kurban G, Hudon V, Duplan E, Ohh M, Pause A. Cancer research. 2006 66:1313-9. [PubMed:16452184]
70
Calcium signaling stimulates translation of HIF-alpha during hypoxia. Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:466-75. [PubMed:16507764]
71
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Cancer research. 2006 66:2725-31. [PubMed:16510593]
72
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC. The Journal of biological chemistry. 2006 281:13957-63. [PubMed:16543245]
73
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. The Journal of biological chemistry. 2006 281:15554-63. [PubMed:16574650]
74
Dynamic HIF1A regulation during human placental development. Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I. Biology of reproduction. 2006 75:112-21. (WB; Human) [PubMed:16611863]
75
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Molecular and cellular biology. 2006 26:3514-26. [PubMed:16611993] [PMC:PMC1447431]
76
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Nakamura K, Martin KC, Jackson JK, Beppu K, Woo CW, Thiele CJ. Cancer research. 2006 66:4249-55. [PubMed:16618748]
77
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Zheng X, Ruas JL, Cao R, Salomons FA, Cao Y, Poellinger L, Pereira T. Molecular and cellular biology. 2006 26:4628-41. [PubMed:16738327] [PMC:PMC1489139]
78
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ. The Journal of biological chemistry. 2006 281:22575-85. (WB; Human) [PubMed:16760477]
79
Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Hergovich A, Lisztwan J, Thoma CR, Wirbelauer C, Barry RE, Krek W. Molecular and cellular biology. 2006 26:5784-96. (WB; Human) [PubMed:16847331] [PMC:PMC1592755]
80
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Lutz MS, Burk RD. Cancer research. 2006 66:6903-7. [PubMed:16849532]
81
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S. Cancer research. 2006 66:8083-90. [PubMed:16912185]
82
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M. Carcinogenesis. 2007 28:529-36. (WB) [PubMed:16920734]
83
Differentiation arrest by hypoxia. Lin Q, Lee YJ, Yun Z. The Journal of biological chemistry. 2006 281:30678-83. (WB; Mouse) [PubMed:16926163]
84
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. Carroll PA, Kenerson HL, Yeung RS, Lagunoff M. Journal of virology. 2006 80:10802-12. (IHC-P; Human) [PubMed:16956952] [PMC:PMC1641760]
85
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH. Molecular and cellular biology. 2006 26:8336-46. [PubMed:16966370] [PMC:PMC1636770]
86
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. Chavez JC, Baranova O, Lin J, Pichiule P. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:9471-81. [PubMed:16971531]
87
Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Koizume S, Jin MS, Miyagi E, Hirahara F, Nakamura Y, Piao JH, Asai A, Yoshida A, Tsuchiya E, Ruf W, Miyagi Y. Cancer research. 2006 66:9453-60. (ChrIP) [PubMed:17018600]
88
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, Sufan RI, Roberts AM, Wilson LA, Betten M, Vandewalle C, Berx G, Marsden PA, Irwin MS, Teh BT, Jewett MA, Ohh M. Molecular and cellular biology. 2007 27:157-69. [PubMed:17060462] [PMC:PMC1800649]
89
NAD(P)H oxidases regulate HIF-2alpha protein expression. Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE. The Journal of biological chemistry. 2007 282:8019-26. [PubMed:17200123]
90
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Yan Q, Bartz S, Mao M, Li L, Kaelin WG. Molecular and cellular biology. 2007 27:2092-102. [PubMed:17220275] [PMC:PMC1820491]
91
Acute postnatal ablation of Hif-2alpha results in anemia. Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:2301-6. [PubMed:17284606] [PMC:PMC1892942]
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HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL. The Journal of physiology. 2007 583:753-66. [PubMed:17627993] [PMC:PMC2277012]
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Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Cheng G, Shao Z, Chaudhari B, Agrawal DK. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L1339-47. [PubMed:17873007]
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Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH. Blood. 2008 111:3229-35. [PubMed:18056838] [PMC:PMC2265459]
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Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Chintalapudi MR, Markiewicz M, Kose N, Dammai V, Champion KJ, Hoda RS, Trojanowska M, Hsu T. Carcinogenesis. 2008 29:696-703. [PubMed:18212329] [PMC:PMC2288647]
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Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours. Kubo T, Sugita T, Shimose S, Matsuo T, Arihiro K, Ochi M. The Journal of bone and joint surgery. British volume. 2008 90:364-70. (WB, IHC-P; Human) [PubMed:18310762]
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The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y. Blood. 2008 112:1482-92. [PubMed:18451309]
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The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Lee, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ. Molecular cancer research : MCR. 2008 6:829-42. [PubMed:18505927]
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Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. Dutta D, Ray S, Vivian JL, Paul S. The Journal of biological chemistry. 2008 283:25404-13. [PubMed:18625704] [PMC:PMC2533069]
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Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ. The Journal of biological chemistry. 2008 283:28106-14. [PubMed:18718909] [PMC:PMC2661383]
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A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, Lago TG, Honigman A. Molecular cancer research : MCR. 2008 6:1397-409. (WB; Mouse) [PubMed:18819928]
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Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dtsch J, Rascher W, Gassmann M. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R1973-81. (IHC, WB; Mouse) [PubMed:18832080]
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Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Koh MY, Darnay BG, Powis G. Molecular and cellular biology. 2008 28:7081-95. [PubMed:18838541] [PMC:PMC2593390]
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Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:19898-903. [PubMed:19057008] [PMC:PMC2604934]
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Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, Aketin Z, Behrens J. Molecular and cellular biology. 2009 29:1707-18. [PubMed:19158274] [PMC:PMC2655617]
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Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:2353-8. [PubMed:19168635] [PMC:PMC2650160]
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Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. Walter A, Etienne-Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte PM, Beretz A, Schini-Kerth VB. The Journal of pharmacology and experimental therapeutics. 2009 329:699-707. [PubMed:19193929]
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Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neur. Lomb DJ, Desouza LA, Franklin JL, Freeman RS. Molecular pharmacology. 2009 75:1198-209. (WB; Mouse) [PubMed:19204094] [PMC:PMC2672811]
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HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Schdel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C. The American journal of pathology. 2009 174:1663-74. (WB; Mouse) [PubMed:19349364] [PMC:PMC2671255]
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Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Luu VD, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild PJ, Sulser T, Schraml P, Moch H. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:3297-304. [PubMed:19401348]
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Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. Ndubuizu OI, Chavez JC, LaManna JC. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 297:R158-65. [PubMed:19420289] [PMC:PMC2711700]
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Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE. Blood. 2009 114:844-59. [PubMed:19454749] [PMC:PMC2882173]
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Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ. Molecular pharmacology. 2009 76:588-95. [PubMed:19528198]
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Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW. The Journal of nutrition. 2009 139:1474-9. [PubMed:19535423]
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Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. Bangiyeva V, Rosenbloom A, Alexander AE, Isanova B, Popko T, Schoenfeld AR. BMC cancer. 2009 9:229. [PubMed:19602254] [PMC:PMC2722669]
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Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK. The Journal of biological chemistry. 2009 284:29065-76. [PubMed:19679656] [PMC:PMC2781452]
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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:17910-5. (ChrIP; Human) [PubMed:19805192] [PMC:PMC2764905]
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Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Molecular and cellular biology. 2010 30:344-53. [PubMed:19858293] [PMC:PMC2798291]
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HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, Phlman S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:7130-6. [PubMed:19903792]
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Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. The Journal of biological chemistry. 2010 285:3651-63. [PubMed:19940151] [PMC:PMC2823506]
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Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:20399-404. [PubMed:19948968] [PMC:PMC2787122]
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Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC. Haematologica. 2010 95:776-84. [PubMed:20015878] [PMC:PMC2864384]
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RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC. Nucleic acids research. 2010 38:1922-31. [PubMed:20026589] [PMC:PMC2847224]
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Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T. Cancer research. 2010 70:357-66. [PubMed:20028863]
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Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Copple BL. Liver international : official journal of the International Association for the Study of the Liver. 2010 30:669-82. (WB; Mouse) [PubMed:20158611] [PMC:PMC3111074]
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Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. Wu DC, Paulson RF. PloS one. 2010 5:e11303. (ChrIP; Mouse) [PubMed:20585586] [PMC:PMC2892039]
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Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. Gimm T, Wiese M, Teschemacher B, Deggerich A, Schdel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Hning S, Eckardt KU, Warnecke C. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 24:4443-58. (WB, ChrIP; Human) [PubMed:20624928]
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Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells. Hu Z, Gulec S, Collins JF. American journal of physiology. Cell physiology. 2010 299:C930-8. [PubMed:20702690] [PMC:PMC2980301]
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Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision. Lange C, Caprara C, Tanimoto N, Beck S, Huber G, Samardzija M, Seeliger M, Grimm C. Neurobiology of disease. 2011 41:119-30. [PubMed:20817091]
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EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. Bougatef F, Menashi S, Khayati F, Nami B, Porcher R, Podgorniak MP, Millot G, Janin A, Calvo F, Lebb C, Mourah S. PloS one. 2010 5:e12265. (ICC, IHC, WB; Human) [PubMed:20824203] [PMC:PMC2930842]
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A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1 and HIF-2. Ren H, Liu NY, Song XF, Ma YS, Zhai XY. Investigative ophthalmology & visual science. 2011 52:3112-8. (WB; Mouse) [PubMed:21228376]
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VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:1931-6. (WB; Human) [PubMed:21233420] [PMC:PMC3033256]
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NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Di Renzo G, Annunziato L. Stroke; a journal of cerebral circulation. 2011 42:754-63. (WB, ChrIP; Human) [PubMed:21293012]
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Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2: role in modulating secretion. Brown ST, Reyes EP, Nurse CA. Biochemical and biophysical research communications. 2011 412:466-72. [PubMed:21840298]
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Epigenetic regulation of HIF-1 in renal cancer cells involves HIF-1/2 binding to a reverse hypoxia-response element. Xu J, Wang B, Xu Y, Sun L, Tian W, Shukla D, Barod R, Grillari J, Grillari-Voglauer R, Maxwell PH, Esteban MA. Oncogene. 2012 31:1065-72. [PubMed:21841824]
184
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. Oncogene. 2012 31:1757-70. (WB; Human) [PubMed:21860410] [PMC:PMC3223555]
185
Hypoxia-inducible factor-2 regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS. Cell death and differentiation. 2012 19:440-50. [PubMed:21869830] [PMC:PMC3278727]
186
Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2 through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, Nakano Y. Biochemical and biophysical research communications. 2011 413:201-5. [PubMed:21888897]
187
Hypoxia modulates the undifferentiated phenotype of human renal inner medullary CD133+ progenitors through Oct4/miR-145 balance. Bussolati B, Moggio A, Collino F, Aghemo G, D'Armento G, Grange C, Camussi G. American journal of physiology. Renal physiology. 2012 302:F116-28. [PubMed:21900452]
188
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:16369-74. (IHC, WB, IHC-P; Mouse, Human) [PubMed:21911388] [PMC:PMC3182724]
189
Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. Shen GM, Zhao YZ, Chen MT, Zhang FL, Liu XL, Wang Y, Liu CZ, Yu J, Zhang JW. The Biochemical journal. 2012 441:675-83. [PubMed:21970364]
190
Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:17544-9. [PubMed:21976486] [PMC:PMC3198321]
191
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Farrow EG, Yu X, Summers LJ, Davis SI, Fleet JC, Allen MR, Robling AG, Stayrook KR, Jideonwo V, Magers MJ, Garringer HJ, Vidal R, Chan RJ, Goodwin CB, Hui SL, Peacock M, White KE. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:E1146-55. [PubMed:22006328] [PMC:PMC3219119]
192
JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Kanno T, Kamba T, Yamasaki T, Shibasaki N, Saito R, Terada N, Toda Y, Mikami Y, Inoue T, Kanematsu A, Nishiyama H, Ogawa O, Nakamura E. Oncogene. 2012 31:3098-110. [PubMed:22020339]
193
Herpesvirus entry mediator regulates hypoxia-inducible factor-1 and erythropoiesis in mice. Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, van Rooijen N, Chen L, Strome SE, Hancock WW, Chen L, Tamada K. The Journal of clinical investigation. 2011 121:4810-9. [PubMed:22080867] [PMC:PMC3225994]
194
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. Veeranna RP, Haque M, Davis DA, Yang M, Yarchoan R. Journal of virology. 2012 86:1097-108. (WB, ChrIP; Human) [PubMed:22090111] [PMC:PMC3255810]
195
Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G. International journal of cancer. Journal international du cancer. 2012 131:E603-13. [PubMed:22095574]
196
Effects of oxygen on zonal marker expression in human articular chondrocytes. Schrobback K, Malda J, Crawford RW, Upton Z, Leavesley DI, Klein TJ. Tissue engineering. Part A. 2012 18:920-33. (ICC, IHC-Fr; Human) [PubMed:22097912]
197
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Nature. 2012 481:380-4. [PubMed:22101433]
198
HIF-2 expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1 is repressed. Munksgaard Persson M, Johansson ME, Monsef N, Planck M, Beckman S, Seckl MJ, Rnnstrand L, Phlman S, Pettersson HM. The American journal of pathology. 2012 180:494-504. [PubMed:22115707]
199
Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. Zhou W, Dosey TL, Biechele T, Moon RT, Horwitz MS, Ruohola-Baker H. PloS one. 2011 6:e27460. [PubMed:22132102] [PMC:PMC3223176]
200
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. Bohonowych JE, Peng S, Gopal U, Hance MW, Wing SB, Argraves KM, Lundgren K, Isaacs JS. BMC cancer. 2011 11:520. [PubMed:22172030] [PMC:PMC3259130]
201
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Molecular and cellular biology. 2012 32:929-40. [PubMed:22215620] [PMC:PMC3295200]
202
Prostate cancer cell lines under hypoxia exhibit greater stem-like properties. Ma Y, Liang D, Liu J, Axcrona K, Kvalheim G, Stokke T, Nesland JM, Suo Z. PloS one. 2011 6:e29170. [PubMed:22216200] [PMC:PMC3247249]
203
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. Hubbi ME, Gilkes DM, Baek JH, Semenza GL. The Journal of biological chemistry. 2012 287:6139-49. [PubMed:22219185] [PMC:PMC3307273]
204
Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Wiese M, Gerlach RG, Popp I, Matuszak J, Mahapatro M, Castiglione K, Chakravortty D, Willam C, Hensel M, Bogdan C, Jantsch J. Infection and immunity. 2012 80:1455-66. (WB; Mouse) [PubMed:22252868] [PMC:PMC3318416]
205
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, Clouthier SG, Wicha MS. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:2784-9. [PubMed:22308314] [PMC:PMC3286974]
206
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG. Nature. 2012 483:484-8. [PubMed:22343896]
207
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E. Journal of biomolecular screening. 2012 17:572-80. (WB; Human) [PubMed:22357874]
208
Chronic nicotine induces hypoxia inducible factor-2 in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Salman S, Brown ST, Nurse CA. American journal of physiology. Cell physiology. 2012 302:C1531-8. (WB; Rat) [PubMed:22403787]
209
Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities. Poey ME, Albini M, Saona G, Lavia M. Microbial pathogenesis. 2012 52:292-301. (WB; Human) [PubMed:22406645]
210
Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model. Yu B, Li MH, Wang W, Wang YQ, Jiang Y, Yang SP, Yue JM, Ding J, Miao ZH. Journal of molecular medicine (Berlin, Germany). 2012 90:971-81. (WB; Human) [PubMed:22406864]
211
Blockade of p53 by HIF-2, but not HIF-1, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Xu Y, Li Y, Pang Y, Ling M, Shen L, Jiang R, Zhao Y, Zhou J, Wang X, Liu Q. Archives of toxicology. 2012 86:947-59. (WB; Human) [PubMed:22447124]
212
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. Cell. 2012 149:63-74. (IHC; Mouse) [PubMed:22464323] [PMC:PMC3408231]
213
The Role of Hypoxia-Inducible Factor-1 and -2 in Androgen Insensitive Prostate Cancer Cells. Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Hayashi I, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. Urologic oncology. 2012 (WB; Human) [PubMed:22537539]
214
Expression and stability of hypoxia inducible factor 1 in osteosarcoma. El Naggar A, Clarkson P, Zhang F, Mathers J, Tognon C, Sorensen PH. Pediatric blood & cancer. 2012 59:1215-22. (WB; Human) [PubMed:22544557]
215
Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF. Molecular and cellular biology. 2012 32:3081-94. (WB; Human) [PubMed:22645311] [PMC:PMC3434507]
216
EMT and stem cell-like properties associated with HIF-2 are involved in arsenite-induced transformation of human bronchial epithelial cells. Xu Y, Li Y, Pang Y, Ling M, Shen L, Yang X, Zhang J, Zhou J, Wang X, Liu Q. PloS one. 2012 7:e37765. (WB; Human) [PubMed:22662215] [PMC:PMC3360629]
217
Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization. Zhou Q, Chen T, Ibe JC, Raj JU, Zhou G. FEBS letters. 2012 586:1510-5. (WB; Human) [PubMed:22673518]
218
An oxygen-regulated switch in the protein synthesis machinery. Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S. Nature. 2012 486:126-9. (WB; Human) [PubMed:22678294]
219
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2. Pourvali K, Matak P, Latunde-Dada GO, Solomou S, Mastrogiannaki M, Peyssonnaux C, Sharp PA. FEBS letters. 2012 586:2423-7. (WB; Human) [PubMed:22684009]
220
Functional importance of Dicer protein in the adaptive cellular response to hypoxia. Ho JJ, Metcalf JL, Yan MS, Turgeon PJ, Wang JJ, Chalsev M, Petruzziello-Pellegrini TN, Tsui AK, He JZ, Dhamko H, Man HS, Robb GB, Teh BT, Ohh M, Marsden PA. The Journal of biological chemistry. 2012 287:29003-20. (WB; Mouse, Human) [PubMed:22745131] [PMC:PMC3436557]
221
Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1 via activation of PGE(2)-cAMP signaling. Lee J, Jung E, Hyun JW, Park D. Journal of cellular biochemistry. 2012 113:3681-91. (WB; Human) [PubMed:22753248]
222
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S. The Journal of cell biology. 2012 198:103-14. (WB, IP, ChrIP; Mouse) [PubMed:22753893] [PMC:PMC3392936]
223
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1955-65. (WB; Mouse) [PubMed:22786772]
224
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM. BMC cancer. 2012 12:293. (IHC, WB; Human) [PubMed:22804960] [PMC:PMC3466155]
225
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H. Neoplasia (New York, N.Y.). 2012 14:535-46. (WB, ChrIP; Human) [PubMed:22806541] [PMC:PMC3394196]
226
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. Chen R, Xu M, Hogg RT, Li J, Little B, Gerard RD, Garcia JA. The Journal of biological chemistry. 2012 287:30800-11. (WB, IP; Human) [PubMed:22807441] [PMC:PMC3436323]
227
Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. Lee SW, Jeong HK, Lee JY, Yang J, Lee EJ, Kim SY, Youn SW, Lee J, Kim WJ, Kim KW, Lim JM, Park JW, Park YB, Kim HS. EMBO molecular medicine. 2012 4:924-38. (WB; Mouse) [PubMed:22821840] [PMC:PMC3491825]
228
Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats. Mihaylova S, Killian A, Mayer K, Pullamsetti SS, Schermuly R, Rosengarten B. Journal of neuroinflammation. 2012 9:183. (WB; Rat) [PubMed:22830560] [PMC:PMC3425315]
229
Hypoxia-inducible factor-1 (HIF1) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K. The Journal of biological chemistry. 2012 287:31962-72. (WB, ChrIP; Human) [PubMed:22843691] [PMC:PMC3442528]
230
Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. Muratsu-Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. PloS one. 2012 7:e41462. (WB; Human) [PubMed:22859986] [PMC:PMC3408438]
231
Stabilization of HIF-2 through redox regulation of mTORC2 activation and initiation of mRNA translation. Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Oncogene. 2012 (WB; Human) [PubMed:22869144]
232
The hypoxia-inducible factor-C/EBP axis controls ethanol-mediated hepcidin repression. Anderson ER, Taylor M, Xue X, Martin A, Moons DS, Omary MB, Shah YM. Molecular and cellular biology. 2012 32:4068-77. (WB; Mouse) [PubMed:22869521] [PMC:PMC3457545]
233
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1 and HIF2 in tumor-associated fibroblasts and human breast cancer cells. Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:3280-9. (ICC, WB; Human) [PubMed:22894905] [PMC:PMC3466527]
234
Suppression of glioma progression by Egln3. Sciorra VA, Sanchez MA, Kunibe A, Wurmser AE. PloS one. 2012 7:e40053. (WB; Human, Rat) [PubMed:22905089] [PMC:PMC3414484]
235
CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Thomas S, Harding MA, Smith SC, Overdevest JB, Nitz MD, Frierson HF, Tomlins SA, Kristiansen G, Theodorescu D. Cancer research. 2012 72:5600-12. (WB; Human) [PubMed:22926560] [PMC:PMC3488144]
236
Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, Yamada T, Kondo K, Kamoto T, Nishiyama H, Ogawa O, Nakamura E. Cancer science. 2012 103:2027-37. (WB; Human) [PubMed:22931246]
237
Hypoxia regulates CD44 and its variant isoforms through HIF-1 in triple negative breast cancer. Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. PloS one. 2012 7:e44078. (WB; Human) [PubMed:22937154] [PMC:PMC3429433]
238
L-2-Oxothiazolidine-4-Carboxylic Acid or -Lipoic Acid Attenuates Airway Remodeling: Involvement of Nuclear Factor-B (NF-B), Nuclear Factor Erythroid 2p45-Related Factor-2 (Nrf2), and Hypoxia-Inducible Factor (HIF). Park SJ, Lee KS, Lee SJ, Kim SR, Park SY, Jeon MS, Lee HB, Lee YC. International journal of molecular sciences. 2012 13:7915-37. (WB; Mouse) [PubMed:22942681] [PMC:PMC3430212]
239
Upstream stimulatory factor 2 and hypoxia-inducible factor 2 (HIF2) cooperatively activate HIF2 target genes during hypoxia. Pawlus MR, Wang L, Ware K, Hu CJ. Molecular and cellular biology. 2012 32:4595-610. (WB, ChrIP; Human) [PubMed:22966206] [PMC:PMC3486188]
240
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA. The Journal of experimental medicine. 2012 209:1985-2000. (WB; Human) [PubMed:23027923] [PMC:PMC3478924]
241
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. Vaapil M, Helczynska K, Villadsen R, Petersen OW, Johansson E, Beckman S, Larsson C, Phlman S, Jgi A. PloS one. 2012 7:e46543. (IHC, WB; Human) [PubMed:23029547] [PMC:PMC3460905]
242
Hypoxia-inducible factor-2 is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Xue X, Shah YM. Carcinogenesis. 2013 34:163-9. (ChrIP; Mouse) [PubMed:23042097] [PMC:PMC3534191]
243
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. Salnikov AV, Liu L, Platen M, Gladkich J, Salnikova O, Ryschich E, Mattern J, Moldenhauer G, Werner J, Schemmer P, Bchler MW, Herr I. PloS one. 2012 7:e46391. (ICC, IHC; Human) [PubMed:23050024] [PMC:PMC3458836]
244
Autophagy creates a CTL epitope that mimics tumor-associated antigens. Demachi-Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K. PloS one. 2012 7:e47126. (WB; Human) [PubMed:23071732] [PMC:PMC3469533]
245
Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. Havasi A, Haegele JA, Gall JM, Blackmon S, Ichimura T, Bonegio RG, Panchenko MV. The American journal of pathology. 2013 182:152-62. [PubMed:23159946] [PMC:PMC3532714]
246
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE, Maguire PB. Blood. 2013 121:188-96. [PubMed:23160460] [PMC:PMC3538329]
247
The accumulations of HIF-1 and HIF-2 by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Xu Y, Li Y, Li H, Pang Y, Zhao Y, Jiang R, Shen L, Zhou J, Wang X, Liu Q. Toxicology and applied pharmacology. 2013 266:187-97. (WB; Human) [PubMed:23194660]
248
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagu J. Nature medicine. 2013 19:50-6. (WB; Mouse) [PubMed:23223005] [PMC:PMC3540187]
249
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. Huang C, Hales BF. PloS one. 2012 7:e51937. (IHC, WB; Mouse) [PubMed:23251655] [PMC:PMC3522594]
250
Mitochondrial respiration and redox coupling in articular chondrocytes. Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM. Arthritis research & therapy. 2015 17:54. (WB; Human) [Full Text Article] [PubMed:25889867] [PMC:PMC4384316] Related Antibodies: LS-B501.
251
Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N. Molecular and cellular biology. 2015 35:2658-72. (WB; Human) [Full Text Article] [PubMed:26012551] [PMC:PMC4524113]
252
Detection of novel metabolite for Roxadustat doping by global metabolomics. Daisuke Saigusa, Norio Suzuki, Yotaro Matsumoto, Keiko Umeda, Yoshihisa Tomioka, Seizo Koshiba, Masayuki Yamamoto. Journal of biochemistry. 2018 February; [Full Text Article] [PubMed:29438490]
253
An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts. Koji Sato, Ikuo Hirano, Hiroki Sekine, Kenichiro Miyauchi, Taku Nakai, Koichiro Kato, Sadayoshi Ito, Masayuki Yamamoto, Norio Suzuki. Scientific reports. 2019 August;9:11254. [Full Text Article] [PubMed:31375751] [PMC:PMC6677766]
254
Silencing of int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease. Okamoto N, Tanaka A, Jung K, Karasawa K, Orito K, Matsuda A, Amagai Y, Oida K, Ohmori K, Matsuda H. Cardiovascular research. 2011 Nov;92:209-17. [Full Text Article] [PubMed:21771896] Related Antibodies: LS-B501.
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HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IHC-plus™ HIF2A / EPAS1 Antibody (aa535-631, clone ep190b) LS-B501
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(2) Publication(s)
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa535-631) (ep190b) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, Biotin) LS-C140825
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa535-631) (Biotin) (Ep190b) Antibody
Mouse, Rat, Hamster, Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, DY550) LS-C140828
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa535-631) (DY550) (Ep190b) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, DY650) LS-C140826
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa535-631) (DY650) (Ep190b) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (aa535-631, clone Ep190b, DY488) LS-C140827
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa535-631) (DY488) (Ep190b) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A / EPAS1 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IHC-plus™ HIF2A / EPAS1 Antibody (clone EP190b) LS-B10429
(4.0) Rating
HIF2A / EPAS1 Mouse anti-Human Monoclonal (EP190b) Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$460
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IHC-plus™ HIF2A / EPAS1 Antibody LS-B4223
(4.0) Rating
HIF2A / EPAS1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IHC-plus™ HIF2A / EPAS1 Antibody (C-Terminus) LS-B517
(4.0) Rating
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Fish, Hamster, Mouse, Sheep, Rat, Human, Primate
IHC, IHC-P
Unconjugated
0.1 ml/$460
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (C-Terminus, Biotin) LS-C83703
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Fish, Hamster, Mouse, Sheep, Rat, Human, Primate
ICC, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (C-Terminus, DY650) LS-C140799
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Fish, Rat, Mouse, Human
ICC, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (C-Terminus, DY550) LS-C140801
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Fish, Rat, Mouse, Human
ICC, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - Anti-HIF2A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (C-Terminus, DY488) LS-C140800
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Fish, Rat, Mouse, Human
ICC, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
HIF2A / EPAS1 Antibody - EPAS1 / HIF2A antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HIF2A / EPAS1 Antibody (aa360-409) LS-C109647
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (aa360-409) Antibody
Human
WB
Unconjugated
100 µl/$424
HIF2A / EPAS1 Antibody - Immunohistochemistry of EPAS-1 antibody
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HIF2A / EPAS1 Antibody (380-420 aa) LS-C387091
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (380-420 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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HIF2A / EPAS1 Antibody (C-Terminus) LS-C123798
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
100 µl/$668
HIF2A / EPAS1 Antibody - Anti-Epas1 Antibody (C-term)at 1:2000 dilution + mouse heart lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 97 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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HIF2A / EPAS1 Antibody (aa713-747) LS-C392718
HIF2A / EPAS1 Rabbit anti-Mouse Polyclonal (aa713-747) Antibody
Mouse
Peptide-ELISA, WB
Unconjugated
400 µl/$393
HIF2A / EPAS1 Antibody - Immunofluorescence of monoclonal antibody to EPAS1 on HeLa cell . [antibody concentration 10 ug/ml]
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HIF2A / EPAS1 Antibody (clone 1G2) LS-C197138
HIF2A / EPAS1 Mouse anti-Human Monoclonal (1G2) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
HIF2A / EPAS1 Antibody - Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-EPAS1 mouse monoclonal antibody.
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HIF2A / EPAS1 Antibody (aa584-870, clone OTI2A6) LS-C793835
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa584-870) (OTI2A6) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
HIF2A / EPAS1 Antibody - Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-EPAS1 mouse monoclonal antibody.
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HIF2A / EPAS1 Antibody (aa584-870, clone OTI2A6, Carrier-free) LS-C789323
HIF2A / EPAS1 Mouse anti-Human Monoclonal (aa584-870) (Carrier-free) (OTI2A6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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HIF2A / EPAS1 Antibody LS-C836087
HIF2A / EPAS1 Rabbit Recombinant Monoclonal Antibody
ChIP-Seq, ICC, ICC-IF, IHC, IP, WB
Unconjugated
20 µl/$299; 100 µl/$425
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HIF2A / EPAS1 Antibody (aa124-150) LS-C321132
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (aa124-150) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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HIF2A / EPAS1 Antibody (aa124-150, APC) LS-C213811
HIF2A / EPAS1 Rabbit anti-Human Polyclonal (aa124-150) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
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HIF2A / EPAS1 Antibody (aa202-240) LS-C123799
HIF2A / EPAS1 Rabbit anti-Rat Polyclonal (aa202-240) Antibody
Mouse, Rat
ICC, IHC, WB
Unconjugated
100 µg/$564
HIF2A / EPAS1 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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HIF2A / EPAS1 Antibody LS-C804384
HIF2A / EPAS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HIF2A / EPAS1 Antibody (aa542-874) LS-C143898
HIF2A / EPAS1 Goat anti-Mouse Polyclonal (aa542-874) Antibody
Mouse
IHC, WB
Unconjugated
100 µg/$962
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