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Infectious Disease
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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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HGF / Hepatocyte Growth Factor
hepatocyte growth factor (hepapoietin A; scatter factor)
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
| Gene Name: | hepatocyte growth factor (hepapoietin A; scatter factor) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | HGF, DFNB39, Hepatocyte growth factor, Hepatopoeitin-A, Hepapoietin A, Hepatopoietin-A, Scatter factor), SF, F-TCF, HGFB, HPTA, Scatter factor |
| Target Sequences: | X16323 CAA34387.1 P14210 |
Publications (6)
1
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-ß in gastric tissue. Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB. Cancer research. 2014 74:2642-51. (WB; Human)
[Full Text Article]
[PubMed:24590056]
[PMC:PMC4158836]
2
Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Piao Y, Park SY, Henry V, Smith BD, Tiao N, Flynn DL, de Groot JF. Neuro-oncology. 2016 September;18:1230-41. (Human)
[Full Text Article]
[PubMed:26965451]
[PMC:PMC4998992]
Related Antibodies: LS-B4657.
3
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y Zaytseva, Kathleen L O'Connor, Craig W Vander Kooi, Side Liu, Qing-Bai She. Nature communications. 2019 August;10:3708. [Full Text Article]
[PubMed:31420553]
[PMC:PMC6697747]
☰ Filters
Products
Proteins
(33)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(7)
Recombinant
(25)
Target
HGF / Hepatocyte Growth Factor
(33)
Publications
No
(33)
Tag
6His, C-terminus
(2)
6His, N-terminus
(3)
GST
(2)
GST, N-terminus
(2)
His
(4)
His, N-terminus
(1)
His,C-terminus
(1)
His-T7
(2)
Myc-DDK (Flag)
(7)
Species
Dog
(1)
Human
(22)
Mouse
(4)
Rabbit
(1)
Rat
(2)
Source
293T Cells
(3)
CHO Cells
(1)
E. coli
(10)
HEK 293 Cells
(10)
High Five Cells
(2)
Human Cells
(1)
Insect Cells
(1)
Mammalian Cells
(3)
Wheat Germ Extract
(2)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(11)
Biologically Active
Biologically active
(8)
High Five Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
2 µg/$268; 10 µg/$349
High Five Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
5 µg/$268; 20 µg/$349
E. coli
His, N-terminus
20.4 kDa
10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
HEK 293 Cells
6His, N-terminus
80 kDa
10 µg/$289; 50 µg/$360
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
80.7kD
10 µg/$288; 50 µg/$442
HEK 293 Cells
Myc-DDK (Flag)
79.6 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST, N-terminus
2 µg/$439
HEK 293 Cells
Myc-DDK (Flag)
83.13 kDa
100 µg/$710
293T Cells
Myc-DDK (Flag)
83.13 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
33.77 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
33.23 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
33.77 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
33.23 kDa
100 µg/$494
HEK 293 Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
10 µg/$395
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
79.7 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
160.4 kDa
10 µg/$288; 50 µg/$436
Insect Cells
None
Biologically active
Less than 0.1 ng/µg of protein.
The alpha and beta chains contains 463 and 234 amino acids and have a predicted molecular mass of approximately 53.6 and 26 kD respectively. The predicted N-terminal amino acids are Gln and Val.
2 µg/$272; 10 µg/$352
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
80.4 kDa
10 µg/$288; 50 µg/$436
HEK 293 Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
1 mg/$7,939
HEK 293 Cells
None
Biologically active
79.4 kDa or 68-85 kDa
5 µg/$268; 25 µg/$349
E. coli
232 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
25.63 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
E. coli
GST
55.4 kD
100 µg/$500; 20 µg/$364; 1 mg/$1,679
E. coli
His
30.0 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
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product results
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