GSK3A / GSK3 Alpha

glycogen synthase kinase 3 alpha

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

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Products

Antibodies (119)

Type

Primary (119)

Target

GSK3A / GSK3 Alpha (119)

Reactivity

Human (91)

Mouse (65)

Rat (59)

Bovine (6)

Chimpanzee (3)

Dog (4)

Drosophila (14)

Gibbon (3)

Insect (1)

Monkey (8)

Pig (3)

Zebrafish (2)

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Application

IHC (50)

IHC-P (11)

WB (105)

ELISA (41)

ICC (9)

IF (9)

IP (13)

Peptide-ELISA (7)

Host

rabbit (93)

mouse (26)

Product Group

IHCPlus (2)

Isotype

Ig (1)

IgG (54)

IgG1 (11)

IgG1,k (6)

IgG2a (6)

IgG2b (1)

Clonality

monoclonal mc (27)

polyclonal pc (92)

Clone

6G12C2 (2)

6G2F1, 6G2F2 (2)

IgG1 (1)

Format

APC (3)

APC Conjugated (8)

Azide-free (3)

Biotin Conjugated (10)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (10)

HRP Conjugated (12)

PE Conjugated (8)

Sepharose 4B Conjugated (1)

Unconjugated (64)

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Epitope

pSer21 (14)

N-Terminus (11)

aa115-409 (8)

aa122-406 (8)

aa122-416 (8)

aa348-376 (7)

aa448-478 (7)

aa203-219, pTyr216/279 (5)

10-90 aa (2)

pTyr279/Tyr216 (2)

Gly15 (1)

Gly273/120 (1)

Ser21 (1)

aa10-59 (1)

aa16-25 (1)

aa203-219 (1)

aa348-382 (1)

p21 (1)

p279/216 (1)

pTyr279,pTyr216 (1)

pTyr279/216 (1)

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Publications

No (119)

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GSK3A / GSK3 Alpha Antibody (phospho-Ser21) LS-C36507

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Monoclonal (pSer21) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$665

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GSK3A / GSK3 Alpha Antibody LS-C123632

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Zebrafish, Drosophila, Rat, Mouse, Bovine, Human, Monkey

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

Select

GSK3A / GSK3 Alpha Antibody (aa348-376) LS-C164395

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Mouse Polyclonal (aa348-376) Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

GSK3A / GSK3 Alpha Antibody (aa203-219) LS-C23951

Antibody:

GSK3A / GSK3 Alpha Mouse anti-Drosophila Monoclonal (aa203-219) Antibody

Reactivity:

Insect, Drosophila

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$907

Select

GSK3A / GSK3 Alpha Antibody (phospho-Ser21) LS-C352302

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

GSK3A / GSK3 Alpha Antibody (N-Terminus) LS-C359015

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

GSK3A / GSK3 Alpha Antibody (phospho-Tyr279/Tyr216) LS-C7155

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pTyr279/Tyr216) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

10 Blots/$842

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GSK3A / GSK3 Alpha Antibody (phospho-Tyr279/Tyr216) LS-C36511

Antibody:

GSK3A / GSK3 Alpha Mouse anti-Drosophila Monoclonal (pTyr279/Tyr216) Antibody

Reactivity:

Drosophila

Applications:

WB

Format:

Unconjugated

Price:

200 µg/$872

Select

IHC-plus™ GSK3A / GSK3 Alpha Antibody (aa448-478) LS-B10711

(4.0) Rating

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (aa448-478) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

Select

IHC-plus™ GSK3A / GSK3 Alpha Antibody LS-B14374

(4.0) Rating

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

GSK3A / GSK3 Alpha Antibody (phospho-Ser21) LS-C808526

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

GSK3A / GSK3 Alpha Antibody (10-90 aa) LS-C380729

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (10-90 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

GSK3A / GSK3 Alpha Antibody (10-90 aa) LS-C383889

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (10-90 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

GSK3A / GSK3 Alpha Antibody LS-C801606

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

GSK3A / GSK3 Alpha Antibody (phospho-Ser21) LS-C129369

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody

Reactivity:

Zebrafish, Drosophila, Rat, Mouse, Bovine, Human, Monkey

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

Select

GSK3A / GSK3 Alpha Antibody LS-C500121

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

GSK3A / GSK3 Alpha Antibody (aa348-376) LS-C329613

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Mouse Polyclonal (aa348-376) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

GSK3A / GSK3 Alpha Antibody (aa348-376, PE) LS-C214982

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Mouse Polyclonal (aa348-376) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• PE

• Unconjugated
• PE

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GSK3A / GSK3 Alpha Antibody (aa10-59) LS-C199030

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (aa10-59) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

GSK3A / GSK3 Alpha Antibody (phospho-Ser21) LS-C117368

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

GSK3A / GSK3 Alpha Antibody (Gly15) LS-C176051

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (Gly15) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

GSK3A / GSK3 Alpha Antibody (phospho-Ser21) LS-C177904

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

GSK3A / GSK3 Alpha Antibody LS-C801607

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

GSK3A / GSK3 Alpha Antibody (phospho-Tyr279,pTyr216) LS-C808525

Antibody:

GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pTyr279,pTyr216) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

GSK3A / GSK3 Alpha Antibody (clone IgG1) LS-C47220

Antibody:

GSK3A / GSK3 Alpha Mouse anti-Human Monoclonal (IgG1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$393

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