Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
GSK3A / GSK3 Alpha
glycogen synthase kinase 3 alpha
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
| Gene Name: | glycogen synthase kinase 3 alpha |
| Family/Subfamily: | Protein Kinase , GSK-3 |
| Synonyms: | GSK3A, GSK-3 alpha, GSK3 alpha |
| Target Sequences: | NM_019884 NP_063937.2 P49840 |
Publications (1)
1
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Shakoori A, Mai W, Miyashita K, Yasumoto K, Takahashi Y, Ooi A, Kawakami K, Minamoto T. Cancer science. 2007 98:1388-93. (IHC)
[PubMed:17640304]
☰ Filters
Products
Antibodies
(119)
ELISA Kits
(25)
Proteins
(7)
Type
Cell-Based
(2)
Cell-Based Phosphorylation
(2)
Competitive EIA
(1)
Custom
(2)
Over-Expression Lysate
(2)
Primary
(119)
Recombinant
(5)
Sandwich
(15)
Sandwich CLIA
(3)
Target
GSK3A / GSK3 Alpha
(151)
Reactivity
Human
(101)
Mouse
(73)
Rat
(69)
Bovine
(6)
Chicken
(1)
Chimpanzee
(3)
Dog
(4)
Drosophila
(14)
Gibbon
(3)
Insect
(1)
Monkey
(9)
Pig
(3)
Porcine
(1)
Rabbit
(1)
Sheep
(1)
Zebrafish
(2)
Application
IHC
(50)
IHC-P
(11)
WB
(105)
ELISA
(41)
ICC
(9)
IF
(9)
IP
(13)
Peptide-ELISA
(7)
Host
rabbit
(93)
mouse
(26)
Product Group
IHCPlus
(2)
Isotype
Ig
(1)
IgG
(54)
IgG1
(11)
IgG1,k
(6)
IgG2a
(6)
IgG2b
(1)
Clonality
monoclonal mc
(27)
polyclonal pc
(92)
Clone
6G12C2
(2)
6G2F1, 6G2F2
(2)
IgG1
(1)
Format
12 x 8-Well Microstrips
(3)
96-Well Microplate
(7)
96-Well Strip Plate
(15)
APC
(3)
APC Conjugated
(8)
Azide-free
(3)
Biotin Conjugated
(10)
Cy3 Conjugated
(3)
Cy7 Conjugated
(3)
FITC Conjugated
(10)
HRP Conjugated
(12)
PE Conjugated
(8)
Sepharose 4B Conjugated
(1)
Unconjugated
(64)
Epitope
pSer21
(14)
N-Terminus
(11)
aa115-409
(8)
aa122-406
(8)
aa122-416
(8)
aa348-376
(7)
aa448-478
(7)
aa203-219, pTyr216/279
(5)
10-90 aa
(2)
pTyr279/Tyr216
(2)
Gly15
(1)
Gly273/120
(1)
Ser21
(1)
aa10-59
(1)
aa16-25
(1)
aa203-219
(1)
aa348-382
(1)
p21
(1)
p279/216
(1)
pTyr279,pTyr216
(1)
pTyr279/216
(1)
Publications
No
(151)
Sample Type
Adherent Cell Cultures
(4)
Plasma
(12)
Serum
(12)
Tissue Homogenates
(5)
Tag
GST, N-terminus
(1)
His
(1)
His-GST
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(4)
Mouse
(1)
Rat
(1)
Source
293T Cells
(1)
E. coli
(3)
HEK 293 Cells
(2)
Wheat Germ Extract
(1)
GSK3A / GSK3 Alpha Rabbit anti-Human Monoclonal (pSer21) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$665
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody
Zebrafish, Drosophila, Rat, Mouse, Bovine, Human, Monkey
IF, IHC, WB
Unconjugated
50 µg/$489
GSK3A / GSK3 Alpha Rabbit anti-Mouse Polyclonal (aa348-376) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
400 µl/$393
GSK3A / GSK3 Alpha Mouse anti-Drosophila Monoclonal (aa203-219) Antibody
Insect, Drosophila
ICC, WB
Unconjugated
100 µg/$907
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pTyr279/Tyr216) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 Blots/$842
GSK3A / GSK3 Alpha Mouse anti-Drosophila Monoclonal (pTyr279/Tyr216) Antibody
Drosophila
WB
Unconjugated
200 µg/$872
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (aa448-478) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody
Mouse, Rat, Human
IHC, IP, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
E. coli
His
37.4 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody
Zebrafish, Drosophila, Rat, Mouse, Bovine, Human, Monkey
IF, IHC, WB
Unconjugated
50 µg/$489
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
GSK3A / GSK3 Alpha Rabbit anti-Mouse Polyclonal (aa348-376) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
200 µl/$734
GSK3A / GSK3 Alpha Rabbit anti-Mouse Polyclonal (aa348-376) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (Gly15) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$321; 100 µl/$403
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pSer21) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$328; 100 µl/$419
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GSK3A / GSK3 Alpha Rabbit anti-Human Polyclonal (pTyr279,pTyr216) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25
of 151
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
